Methods for studying the cellular response to DNA damage: Influence of the Mre11 complex on chromosome metabolism Journal Article
| Authors: | Theunissen, J. W. F.; Petrini, J. H. J. |
| Article Title: | Methods for studying the cellular response to DNA damage: Influence of the Mre11 complex on chromosome metabolism |
| Abstract: | Dramatic progress in understanding the mediators and mechanisms of chromosome break metabolism has been made in recent years. As a result, the links between disease and defects in chromosome dynamics have become clearer. In this chapter, we discuss techniques employed in our laboratory to study chromosome break metabolism, which include assessments at the molecular and cellular level. In our laboratory, we use the Mre11 complex as a tool to study this process, but the techniques discussed are of general relevance. |
| Keywords: | mice; fibroblasts; checkpoints; ataxia telangiectasia; double-strand breaks; s-phase; dependent nuclear-dynamics; ionizing irradiation |
| Journal Title: | Methods in Enzymology |
| Volume: | 409 |
| ISSN: | 0076-6879 |
| Publisher: | Academic Press |
| Publication Place: | San Diego |
| Date Published: | 2006-01-01 |
| Start Page: | 251 |
| End Page: | 284 |
| Language: | English |
| ACCESSION: | WOS:000238354800015 |
| PROVIDER: | wos |
| PUBMED: | 16793406 |
| DOI: | 10.1016/s0076-6879(05)09015-4 |
| Notes: | Chapter 15 in "DNA Repair, Part B" (ISBN: 978-0-12-182814-1) -- DNA Repair, Pt B - Review; Book Chapter 15 - 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA - "Source: Wos" |
