Combined intraepidermal neuroendocrine (Merkel cell) and squamous cell carcinoma in situ with CM2B4 negativity and p53 overexpression Journal Article
| Authors: | Tan, B. H.; Busam, K. J.; Pulitzer, M. P. |
| Article Title: | Combined intraepidermal neuroendocrine (Merkel cell) and squamous cell carcinoma in situ with CM2B4 negativity and p53 overexpression |
| Abstract: | Primary cutaneous neuroendocrine carcinoma, also known as Merkel cell carcinoma (MCC), usually presents as a dermal and/or subcutaneous tumor. Rarely, it is confined to the epidermis or adnexal epithelium [MCC in situ (MCCIS)]. Little is known about the spectrum of features and biology of MCCIS. Herein, we report a case of MCCIS arising on the cheek of a 77-year-old Caucasian male, which was associated with squamous cell carcinoma in situ. The tumor cells of both the neuroendocrine and squamous components prominently involved adnexal structures but did not invade the dermis. The tumor cells with neuroendocrine features were immunoreactive for cytokeratin-20, chromogranin and synaptophysin. They also expressed p53 but were non-reactive with the monoclonal antibody CM2B4. Lack of labeling for CM2B4 is in keeping with prior observations of combined squamous and MCC. Our findings support the concept of a distinct subtype of virus-independent cutaneous neuroendocrine carcinoma that differs from conventional MCC. The observed overexpression of p53 suggests that the development of this tumor type may be related to chronic ultraviolet damage. Copyright © 2012 John Wiley & Sons A/S. |
| Keywords: | immunohistochemistry; aged; case report; squamous cell carcinoma; carcinoma, squamous cell; metabolism; skin neoplasms; pathology; protein p53; monoclonal antibody; gene expression regulation; gene expression regulation, neoplastic; skin tumor; biosynthesis; antibodies, monoclonal; chemistry; carcinoma in situ; tumor suppressor protein p53; merkel cell carcinoma; merkel cell tumor; carcinoma, merkel cell; polyomavirus; neoplasms, second primary; second cancer; tp53 protein, human; antibodies, neoplasm; cancer antibody |
| Journal Title: | Journal of Cutaneous Pathology |
| Volume: | 39 |
| Issue: | 6 |
| ISSN: | 0303-6987 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2012-06-01 |
| Start Page: | 626 |
| End Page: | 630 |
| Language: | English |
| DOI: | 10.1111/j.1600-0560.2012.01908.x |
| PROVIDER: | scopus |
| PUBMED: | 22524588 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 July 2012" - "CODEN: JCUPB" - "Source: Scopus" |
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