Merkel cell carcinoma: Review Journal Article
| Authors: | Pulitzer, M. P.; Amin, B. D.; Busam, K. J. |
| Article Title: | Merkel cell carcinoma: Review |
| Abstract: | Merkel cell carcinoma (MCC) is synonymous with primary cutaneous neuroendocrine carcinoma. It tends to affects elderly whites, but there is also an increased incidence among immunosuppressed patients. The recent identification of a novel polyomavirus associated with the tumor has stimulated renewed interest in its pathogenesis. MCC tends to show classic histologic features of a neuroendocrine carcinoma and is often positive for CK20, but nonclassic cytologic findings and unusual immunophenotypes may be observed and can lead to a diagnostic confusion. MCC needs to be distinguished from other primary cutaneous tumors with a small cell appearance and metastatic tumors. Surgical excision is the treatment of choice, but radiation therapy has also found to be effective. Sentinel lymph node biopsy has become an integral part of the staging of patients with MCC. © 2009 Lippincott Williams & Wilkins, Inc. |
| Keywords: | immunohistochemistry; cancer survival; aged; cancer surgery; primary tumor; clinical feature; histopathology; pathogenesis; review; cancer risk; nonhuman; cancer radiotherapy; cancer staging; antineoplastic agent; cancer diagnosis; cancer incidence; sentinel lymph node; sentinel lymph node biopsy; cd3 antigen; phenotype; electron microscopy; glycoprotein gp 100; melanoma; metastasis; basal cell carcinoma; skin neoplasms; differential diagnosis; pathology; tumor marker; skin carcinoma; ewing sarcoma; neuroendocrine tumor; cd20 antigen; skin tumor; cancer cytodiagnosis; neoplasm metastasis; immunophenotyping; merkel cell carcinoma; cytokeratin 20; merkel cell tumor; mixed tumor; polyoma virus; carcinoma, merkel cell; keratin-20; polyomavirus; melan a; cancer epidemiology; age distribution; pathogenicity; monophenol monooxygenase; race difference; caucasian; small cell carcinoma; ck20; immunocompromised patient; sweat gland carcinoma; virus carcinogenesis; virus identification; mixed tumor, malignant |
| Journal Title: | Advances in Anatomic Pathology |
| Volume: | 16 |
| Issue: | 3 |
| ISSN: | 1072-4109 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2009-05-01 |
| Start Page: | 135 |
| End Page: | 144 |
| Language: | English |
| DOI: | 10.1097/PAP.0b013e3181a12f5a |
| PUBMED: | 19395876 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 30 November 2010" - "Source: Scopus" |
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