Feeling the squeeze: Live-cell extrusion limits cell density in epithelia Journal Article
| Authors: | Fernandez-Gonzalez, R.; Zallen, J. A. |
| Article Title: | Feeling the squeeze: Live-cell extrusion limits cell density in epithelia |
| Abstract: | Tissues develop in confined volumes that can impose mechanical constraints on their growth, but it is unclear how cells respond to these limits to regulate tissue size and shape. Two papers show that overcrowding and cell deformation lead to the shedding of live cells to maintain homeostasis in epithelial cell sheets. © 2012 Elsevier Inc. |
| Keywords: | review; nonhuman; cell death; compression; epithelium cell; cell size; cell density; epithelium; cell shape; tissue growth; tissue structure; growth inhibition; mechanical stress; cell extrusion; cell overcrowding; cellular, subcellular and molecular biological phenomena and functions |
| Journal Title: | Cell |
| Volume: | 149 |
| Issue: | 5 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2012-05-25 |
| Start Page: | 965 |
| End Page: | 967 |
| Language: | English |
| DOI: | 10.1016/j.cell.2012.05.006 |
| PROVIDER: | scopus |
| PUBMED: | 22632965 |
| PMCID: | PMC4752205 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 July 2012" - "CODEN: CELLB" - "Source: Scopus" |
