Management of resectable gastrointestinal stromal tumor Journal Article
| Authors: | Chaudhry, U. I.; DeMatteo, R. P. |
| Article Title: | Management of resectable gastrointestinal stromal tumor |
| Abstract: | Gastrointestinal stromal tumor (GIST) is a rare neoplasm that recently has become an intense focus of scientific investigation, as it serves as a model for the molecular therapy for cancer. Although surgery remains the principle treatment of primary localized GIST, imatinib mesylate, a selective inhibitor of KIT protein, achieves dramatic responses in metastatic GIST. Multimodality therapy integrating surgery and molecular therapy has shown promise. This article summarizes the epidemiology, clinicopathologic features, natural history, and clinical management of GIST. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | immunohistochemistry; gene mutation; mutation; histopathology; review; cancer radiotherapy; disease free survival; combined modality therapy; gastrointestinal stromal tumor; imatinib; platelet derived growth factor alpha receptor; stem cell factor; smooth muscle fiber; gastrointestinal stromal tumors; pyrimidines; surgery; kit; pdgfr; gastrointestinal surgery; schwann cell; disease management; piperazines; receptor protein-tyrosine kinases |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 23 |
| Issue: | 1 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-02-01 |
| Start Page: | 79 |
| End Page: | 96 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2009.01.001 |
| PUBMED: | 19248972 |
| PROVIDER: | scopus |
| PMCID: | PMC2664970 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: HCNAE" - "Source: Scopus" |
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