The expanding role of miR-302-367 in pluripotency and reprogramming Journal Article

Authors: Lipchina, I.; Studer, L.; Betel, D.
Article Title: The expanding role of miR-302-367 in pluripotency and reprogramming
Abstract: MicroRNA (miRNA) has been shown to be essential for regulating cell fate and pluripotency; however, our knowledge of miRNA function in stem cells is incomplete due to experimental limitations and difficulties in identifying their physiological targets. Recent studies implicated hESC-expressed miRNAs (miR-302-367 and miR-371-373 clusters) in regulating BMP signaling and promoting pluripotency, suggesting that low levels of BMP signaling may promote pluripotency by preventing neural induction. A comprehensive list of miR-302-367 targets recently identified by genome-wide approaches suggests a number of additional cellular processes and signaling pathways whose regulation by miR-302-367 may promote pluripotency and reprogramming, such as cell cycle, epigenetic changes, metabolism and vesicular transfer. © 2012 Landes Bioscience.
Keywords: signal transduction; unclassified drug; review; nonhuman; cell proliferation; animals; mice; dna damage; cell cycle s phase; microrna; gene expression; cell growth; bone morphogenetic protein; transforming growth factor beta; embryonic stem cell; cell differentiation; neurons; cell population; protein p53; cell lineage; chromatin; cell cycle arrest; stem cells; base sequence; embryonic stem cells; upregulation; pluripotent; cyclin dependent kinase inhibitor 1a; micrornas; endocytosis; octamer transcription factor 4; transcription factor sox2; cell cycle g1 phase; biogenesis; nuclear reprogramming; metabolic regulation; kruppel like factor 4; reprogramming; bone morphogenetic proteins; genetic regulation; transforming growth factor beta receptor 2; mirna; pluripotency; microrna 302; bmp signaling; mir-302-367; microrna 367
Journal Title: Cell Cycle
Volume: 11
Issue: 8
ISSN: 1538-4101
Publisher: Taylor & Francis Inc.  
Date Published: 2012-04-15
Start Page: 1517
End Page: 1523
Language: English
DOI: 10.4161/cc.19846
PROVIDER: scopus
PUBMED: 22436490
Notes: --- - "Export Date: 4 June 2012" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Lorenz Studer
    190 Studer