Reproductive outcomes of patients undergoing radical trachelectomy for early-stage cervical cancer Journal Article
| Authors: | Kim, C. H.; Abu-Rustum, N. R.; Chi, D. S.; Gardner, G. J.; Leitao, M. M.; Carter, J.; Barakat, R. R.; Sonoda, Y. |
| Article Title: | Reproductive outcomes of patients undergoing radical trachelectomy for early-stage cervical cancer |
| Abstract: | Objective: To report the reproductive outcomes of patients undergoing fertility-preserving radical trachelectomy (RT) for the treatment of early-stage cervical cancer. Methods: We analyzed data from our institution's first 105 patients who underwent attempted fertility-sparing surgery with radical trachelectomy, pelvic lymphadenectomy, and cerclage from November 2001 to October 2010. Results: Of the 105 patients who underwent attempted RT, 77 (73%) did not require a conversion to radical hysterectomy or postoperative treatment. The median age was 32 (range, 25-38 years). Most patients (75%) had stage IB1 disease. Sixty-six patients (63%) were nulliparous. Thirty-five women were actively attempting conception 6 months after surgery, and 23 (66%) women were successful in conceiving: there were 20 live births, 3 elective terminations, and 4 spontaneous miscarriages. Four patients had 2 pregnancies each; all delivered their second pregnancy between 32 and 36 weeks. Cerclage erosion through the vaginal wall occurred in 6 cases and was treated by transvaginal removal of protruding suture material. One of these patients experienced a second trimester miscarriage. Conclusions: The majority of women who attempted to conceive after radical trachelectomy were successful, and most of their pregnancies resulted in full-term births. Assisted reproduction played an important role in select women. Cerclage likely contributed to a post-trachelectomy uterine ability to carry a pregnancy to the third trimester. The second post-trachelectomy pregnancy appears to be at higher risk for preterm delivery than the first pregnancy. © 2012 Elsevier B.V. |
| Keywords: | radical trachelectomy; cervical cancer; reproductive outcomes |
| Journal Title: | Gynecologic Oncology |
| Volume: | 125 |
| Issue: | 3 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-06-01 |
| Start Page: | 585 |
| End Page: | 588 |
| Language: | English |
| DOI: | 10.1016/j.ygyno.2012.03.014 |
| PROVIDER: | scopus |
| PUBMED: | 22430614 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 June 2012" - "CODEN: GYNOA" - "Source: Scopus" |
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