Self-seeding in cancer Journal Article
| Authors: | Comen, E.; Norton, L. |
| Article Title: | Self-seeding in cancer |
| Abstract: | Despite significant progress in our understanding and treatment of metastatic cancer, nearly all metastatic cancers are incurable. In this Review, we use breast cancer as a model to highlight the limitations and inconsistencies of our existing treatment paradigms for metastatic disease. In turn, we offer a new theory of metastasis, termed "self-seeding. " The self-seeding paradigm, well validated in mathematical, experimental and animal models, challenges the notion that cancers cells that leave a primary tumor cell, unidirectionally seed metastases in regional lymph nodes and/or distant sites. In contrast, there is mounting evidence that circulating tumor cells can move multi-directionally, seeding not only distant sites but also their tumors of origin. Here, we show that the self-seeding model may answer many of the quandaries intrinsic to understanding how cancer spreads and ultimately kills. Indeed, redirecting our research and treatment efforts within the self-seeding model may offer new possibilities for eradicating metastatic cancer. © 2012 Springer-Verlag Berlin Heidelberg. |
| Keywords: | cancer growth; cancer risk; lymph node metastasis; breast cancer; echomammography; tumor volume; genetic association; tumor biopsy; drug design; risk factor; mathematical model; cancer invasion; axillary lymph node; cancer genetics; intraductal carcinoma; tumor seeding; circulating tumor cell |
| Journal Title: | Recent Results in Cancer Research |
| Volume: | 195 |
| ISSN: | 0080-0015 |
| Publisher: | Springer Verlag |
| Date Published: | 2012-01-01 |
| Start Page: | 13 |
| End Page: | 23 |
| Language: | English |
| DOI: | 10.1007/978-3-642-28160-0_2 |
| PROVIDER: | scopus |
| PUBMED: | 22527491 |
| DOI/URL: | |
| Notes: | Book Chapter in "Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer" (ISBN: 978-3-642-28159-4) (Online ISBN: 978-3-642-28160-0) -- "Cited By (since 1996): 1" -- "Export Date: 4 June 2012" -- "CODEN: RRCRB" -- "Source: Scopus" |
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