Image-guided adaptive radiation therapy with anatomic imaging and dose verification in head and neck cancer using kV CBCT Journal Article
| Authors: | Chan, M. F.; Song, Y.; Burman, C.; Hu, Y. C.; Sim, S. E. |
| Article Title: | Image-guided adaptive radiation therapy with anatomic imaging and dose verification in head and neck cancer using kV CBCT |
| Abstract: | Image-Guided Adaptive Radiation Therapy (IGART) is a promising approach in radiotherapy for bulky head-and-neck tumours. We have developed a methodology for dosimetric replanning using kV-CBCT. A case study is presented in which the CBCT and planning CT (pCT) images were registered to generate Adaptive pCT (ApCT). The registration similarity measure was intensity-based 'Mutual Information'. The search was optimised using the 'downhill simplex' algorithm. Dose-distribution and DVH were re-calculated. The actual dose delivered can be assessed based on the ApCT. Clinical implementation of IGART has potential to compensate for inter-fractional changes, while reducing damage to critical organs and increasing tumour targeting. Copyright © 2012 Inderscience Enterprises Ltd. |
| Keywords: | intensity modulated radiation therapy; radiotherapy; head and neck cancer; imrt; computerized tomography; medical imaging; physical therapy; tumors; igrt; intensity-modulated radiation therapy; diseases; head-and-neck cancer; image-guided radiation therapy; cone-beam ct; 4drt; adaptive radiation therapy; kV cone-beam CT; 4-dimensional radiation therapy; adaptive radiation therapies |
| Journal Title: | International Journal of Biomedical Engineering and Technology |
| Volume: | 8 |
| Issue: | 2-3 |
| ISSN: | 1752-6418 |
| Publisher: | Inderscience Publishers |
| Date Published: | 2012-01-01 |
| Start Page: | 151 |
| End Page: | 166 |
| Language: | English |
| DOI: | 10.1504/IJBET.2012.046083 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 June 2012" - "Source: Scopus" |
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