Radiation exposure of computed tomography and direct intracoronary angiography - Risk has its reward Journal Article
| Authors: | Zanzonico, P.; Rothenberg, L. N.; Strauss, H. W. |
| Article Title: | Radiation exposure of computed tomography and direct intracoronary angiography - Risk has its reward |
| Abstract: | A hallmark of noninvasive testing has been the identification of patients with coronary artery disease. Now, with multislice computed tomography (MSCT), information about coronary anatomy can be obtained without the need for catheterization. A major concern with the application of MSCT coronary angiography is the radiation exposure to the patient. Both MSCT and selective coronary angiography share the risks of procedure-related complications, such as allergic contrast reactions, and stochastic risks (i.e., cancer induction) of low-level radiation. There is a substantially higher radiation dose for MSCT angiography (effective dose [ED] 14 mSv) than for CCA (ED 6 mSv). These exposures yield lifetimes risks of 0.07% and 0.02%, respectively, of inducing a fatal cancer in the general (i.e., age- and gender-averaged) population. However, CCA poses additional serious risks associated with cardiac catheterization, yielding a non-radiogenic risk of mortality-excluding contrast reactions-of 0.11%. Combining the radiogenic and non-radiogenic risks (0.02% and 0.11%, respectively) yields a 0.13% overall risk of mortality from CCA-nearly two-fold higher than that for MSCT angiography (0.07%). If one were to use the lower, more age-appropriate risk factors for the older patient population in question, the radiogenic risks of both CCA and MSCT would be reduced by about one-half, further widening the overall safety ratio of MSCT relative to CCA. When weighing the relative risks of alternative medical procedures, therefore, it is imperative that one consider the overall risk of the respective procedures. © 2006 American College of Cardiology Foundation. |
| Keywords: | mortality; review; radiation dose; computer assisted tomography; tomography, x-ray computed; risk factor; cancer mortality; radiation exposure; risk assessment; radiation dosage; risk; drug hypersensitivity; population research; contrast enhancement; heart infarction; population risk; intermethod comparison; contrast medium; age distribution; radiation hazard; neurological complication; coronary artery disease; non invasive procedure; radiation sickness; computed tomographic angiography; heart hemodynamics; stress echocardiography; radiation carcinogenesis; multidetector computed tomography; artery calcification; heart muscle perfusion; occupational exposure; heart catheterization; angiocardiography; coronary angiography; stable angina pectoris; coronary arteriosclerosis; direct intracoronary angiography; heart ventriculography |
| Journal Title: | Journal of the American College of Cardiology |
| Volume: | 47 |
| Issue: | 9 |
| ISSN: | 0735-1097 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2006-05-02 |
| Start Page: | 1846 |
| End Page: | 1849 |
| Language: | English |
| DOI: | 10.1016/j.jacc.2005.10.075 |
| PUBMED: | 16682311 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 55" - "Export Date: 4 June 2012" - "CODEN: JACCD" - "Source: Scopus" |
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