Multiprotein DNA looping Journal Article
| Authors: | Vilar, J. M. G.; Saiz, L. |
| Article Title: | Multiprotein DNA looping |
| Abstract: | DNA looping plays a fundamental role in a wide variety of biological processes, providing the backbone for long range interactions on DNA. Here we develop the first model for DNA looping by an arbitrarily large number of proteins and solve it analytically in the case of identical binding. We uncover a switchlike transition between looped and unlooped phases and identify the key parameters that control this transition. Our results establish the basis for the quantitative understanding of fundamental cellular processes like DNA recombination, gene silencing, and telomere maintenance. © 2006 The American Physical Society. |
| Keywords: | proteins; telomere; genes; dna; cell culture; gene silencing; parameter estimation; dna looping |
| Journal Title: | Physical Review Letters |
| Volume: | 96 |
| Issue: | 23 |
| ISSN: | 0031-9007 |
| Publisher: | American Physical Society |
| Date Published: | 2006-06-16 |
| Start Page: | 238103 |
| Language: | English |
| DOI: | 10.1103/PhysRevLett.96.238103 |
| PROVIDER: | scopus |
| PUBMED: | 16803410 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 4 June 2012" - "CODEN: PRLTA" - "Source: Scopus" |
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13Saiz-Ardanaz -
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Gomez Vilar
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