Osteonecrosis of the jaw in cancer patients receiving IV bisphosphonates Journal Article
| Authors: | Van Poznak, C.; Estilo, C. |
| Article Title: | Osteonecrosis of the jaw in cancer patients receiving IV bisphosphonates |
| Abstract: | Cases of osteonecrosis of the jaw (ONJ) have been reported with an increasing frequency over the past few years. ONJ is most often identified in patients with cancer who are receiving intravenous bisphosphonate therapy but it has also been diagnosed in patients receiving oral bisphosphonates for nonmalignant conditions. The condition involves exposed bone of the maxilla or mandible. Although it is often associated with a recent dental surgical procedure, spontaneous ONJ can also occur. Patients commonly present with symptoms. Through case reporting and clinical experience, there is a suggestion that the incidence of ONJ in patients with cancer receiving intravenous bisphosphonates ranges between 1% and 10%. Management of ONJ focuses on maximizing oral health, conservative actions with mouth rinses, antibiotics, and avoidance of unnecessary invasive dental procedures. The currently available data on ONJ are reviewed here. |
| Keywords: | bone neoplasms; antibiotic agent; bone tumor; clinical feature; clinical trial; histopathology; review; solid tumor; bone metastasis; cancer patient; nuclear magnetic resonance imaging; metastasis; computer assisted tomography; controlled clinical trial; multiple myeloma; breast cancer; randomized controlled trial; morbidity; bisphosphonic acid derivative; hypercalcemia; pathology; breast neoplasms; bone lesion; chemically induced disorder; breast tumor; osteoclast; bacterial colonization; blood clotting disorder; genetic predisposition; diphosphonates; bone remodeling; maxilla; bone necrosis; oral surgery; bone density conservation agent; jaw disease; bone density conservation agents; jaw diseases; osteonecrosis; alendronic acid; zoledronic acid; mandible; bone radiography; mouthwash; mouth hygiene; pamidronic acid; chlorhexidine gluconate; denosumab; jaw osteonecrosis; oral surgical procedures; jaw; actinomyces; risedronic acid; panoramic radiography; gingival biopsy |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 20 |
| Issue: | 9 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 2006-08-01 |
| Start Page: | 1053 |
| End Page: | 1062 |
| Language: | English |
| PUBMED: | 16986349 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 25" - "Export Date: 4 June 2012" - "CODEN: OCLGE" - "Source: Scopus" |
