Osteonecrosis of the jaw associated with pembrolizumab Journal Article


Authors: Pennings, I.; Moskowitz, A.; Shah, G.; Estilo, C.; Huryn, J. M.; Yom, S. K.
Article Title: Osteonecrosis of the jaw associated with pembrolizumab
Abstract: We report a case of osteonecrosis of the jaw (ONJ) with pembrolizumab, a rare yet possibly emerging complication. In this case, a temporal relationship between the development of ONJ and the patient's treatment regimen suggested an association between pembrolizumab/GVD therapy and the development of ONJ. Thrombocytosis and anatomic factors may also have played a role. The number of patients using pembrolizumab will likely continue to increase. We document this instance in order to better inform dental treatment around cancer patients undergoing pembrolizumab therapy. © 2023 Elsevier Inc.
Journal Title: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume: 136
Issue: 1
ISSN: 2212-4403
Publisher: Elsevier B.V.  
Date Published: 2023-07-01
Start Page: e11
End Page: e14
Language: English
DOI: 10.1016/j.oooo.2022.12.013
PROVIDER: scopus
PUBMED: 36804060
PMCID: PMC10395506
DOI/URL:
Notes: Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is SaeHee Yom -- Source: Scopus
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MSK Authors
  1. Joseph M Huryn
    108 Huryn
  2. Cherry Estilo
    93 Estilo
  3. Alison Moskowitz
    339 Moskowitz
  4. SaeHee Kim Yom
    42 Yom
  5. Gunjan Lalitchandra Shah
    418 Shah