Meiosis: Separase strikes twice Journal Article
| Authors: | Terret, M. E.; Jallepalli, P. V. |
| Article Title: | Meiosis: Separase strikes twice |
| Abstract: | During anaphase, the cysteine protease separase cleaves cohesin and releases sister chromatids. In budding yeast, separase also has a crucial non-proteolytic role in triggering mitotic exit. Separase performs a similar non-catalytic function in frog and mouse oocytes through its physical interaction with cdk1. Vertebrate separase is therefore essential not only for homologue disjunction, but also for bringing about the end of meiosis I. |
| Keywords: | unclassified drug; nonhuman; mitosis; cohesin; cell cycle protein; oocyte; meiosis; animals; cell cycle proteins; chromosomal proteins, non-histone; mice; oocytes; complex formation; sister chromatid; protein degradation; protein protein interaction; molecular dynamics; protein binding; membrane proteins; enzyme activation; nuclear proteins; vertebrata; anura; ubiquitination; serine endopeptidases; messenger rna; saccharomyces cerevisiae; cell cycle arrest; sister chromatid exchange; anaphase; saccharomycetales; saccharomyces cerevisiae protein; cyclin b; vertebrate; apc protein; metaphase; chromosome segregation; cyclin dependent kinase 1; reproduction; xenopus; chromatids; separase; phosphoprotein phosphatase 2a; cdc2 protein kinase; gelatinases; phosphoprotein phosphatase 1; cysteine proteinase; histone h1; cell cycle protein 14; frog |
| Journal Title: | Nature Cell Biology |
| Volume: | 8 |
| Issue: | 9 |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2006-09-01 |
| Start Page: | 910 |
| End Page: | 911 |
| Language: | English |
| DOI: | 10.1038/ncb0906-910 |
| PUBMED: | 16946739 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 4 June 2012" - "CODEN: NCBIF" - "Source: Scopus" |
