Mad2 overexpression promotes aneuploidy and tumorigenesis in mice Journal Article

   

Authors:	Sotillo, R.; Hernando, E.; Diaz-Rodríguez, E.; Teruya-Feldstein, J.; Cordon-Cardo, C.; Lowe, S. W.; Benezra, R.
Article Title:	Mad2 overexpression promotes aneuploidy and tumorigenesis in mice
Abstract:	Mad2 is an essential component of the spindle checkpoint that blocks activation of Separase and dissolution of sister chromatids until microtubule attachment to kinetochores is complete. We show here that overexpression of Mad2 in transgenic mice leads to a wide variety of neoplasias, appearance of broken chromosomes, anaphase bridges, and whole-chromosome gains and losses, as well as acceleration of myc-induced lymphomagenesis. Moreover, continued overexpression of Mad2 is not required for tumor maintenance, unlike the majority of oncogenes studied to date. These results demonstrate that transient Mad2 overexpression and chromosome instability can be an important stimulus in the initiation and progression of different cancer subtypes. © 2007 Elsevier Inc. All rights reserved.
Keywords:	immunohistochemistry; controlled study; histopathology; liver cell carcinoma; nonhuman; nuclear magnetic resonance imaging; magnetic resonance imaging; cancer incidence; neoplasms; mitosis; animal cell; mouse; animals; cell cycle proteins; mice; gene; in situ hybridization, fluorescence; mus; sister chromatid; gene overexpression; gene expression; embryo; animal experiment; animal model; genotype; carcinogenesis; gene transfer; transgenic mouse; mus musculus; mice, transgenic; cell transformation, neoplastic; lymphocyte activation; dna; fibrosarcoma; angiomyolipoma; nucleotide sequence; cancer cell; liver tumor; prostate tumor; lymphoma; retrovirus vector; chromosomal instability; cellcycle; breast adenocarcinoma; oncogene c myc; doxycycline; cyclin b; intestine tumor; tetracycline; microtubule; karyotype; comparative genomic hybridization; fluorescence activated cell sorting; aneuploidy; tumor diagnosis; humdisease; complementary dna; securin; tissue culture; protein mad2; testis atrophy; lung adenoma; mad2 gene
Journal Title:	Cancer Cell
Volume:	11
Issue:	1
ISSN:	1535-6108
Publisher:	Cell Press
Date Published:	2007-01-01
Start Page:	9
End Page:	23
Language:	English
DOI:	10.1016/j.ccr.2006.10.019
PUBMED:	17189715
PROVIDER:	scopus
PMCID:	PMC1850996
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-33845986330&partnerID=40&md5=f3333fe3285ab27a68893459f8e8b279
Notes:	--- - "Cited By (since 1996): 176" - "Export Date: 17 November 2011" - "CODEN: CCAEC" - "Source: Scopus"

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