Femoral fracture risk assessment after Intensity Modulated Radiation Therapy (IMRT) for the treatment of soft tissue sarcoma using a novel mathematical model Conference Paper

  

Authors:	Song, Y.; Wang, S.; Chan, M.; Chandra, B.; Dhawan, A.
Title:	Femoral fracture risk assessment after Intensity Modulated Radiation Therapy (IMRT) for the treatment of soft tissue sarcoma using a novel mathematical model
Conference Title:	28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Abstract:	Intensity modulated radiation therapy (IMRT) is often used for the treatment of soft tissue sarcoma. Due to high radiation doses, many patients have high risk of suffering from a femoral bone fracture sometime following the IMRT treatment The most common type of radiation treatment-related fracture is a stress fracture. The fracture risk rate may be as high as 24% in sarcoma patients who have undergone periosteal stripping and received chemotherapy. Thus, it is necessary to be able to identify those patients with high risk for IMRT treatment-related bone fracture. In this paper, we will first present IMRT treatment planning techniques. We will then discuss how bone system changes their stiffness and how the fracture risk develops after a certain period of time post radiation treatment. Finally, we will present our latest data on the femoral bone fracture risk factor assessment for patients with soft tissue sarcoma following IMRT treatment. We have developed a novel mathematical model of trabecular bone composed of a disordered cubic network. Based on our preliminary data, we believe that this new mathematical model could shed new light on the relationship between the femoral bone fracture risk factor and the radiation dose delivered by an IMRT plan and provide a valuable prognostic tool for these high-risk patients. ©2006 IEEE.
Keywords:	fracture; radiotherapy; risk assessment; soft tissue sarcoma; patient treatment; tissue; dosimeters; mathematical models; intensity modulated radiation therapy (imrt); trabecular bone; bone fracture
Journal Title	IEEE Engineering in Medicine and Biology Society. Conference Proceedings
Conference Dates:	2006 Aug 30-Sep 3
Conference Location:	New York, NY
ISBN:	1557-170X
Publisher:	IEEE
Date Published:	2006-01-01
Start Page:	95
End Page:	98
Language:	English
DOI:	10.1109/IEMBS.2006.260160
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-34047152929&partnerID=40&md5=5d0a8d8dfa0dd8c4013de7d4cfd5ae27
Notes:	--- - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings - Annu Int Conf IEEE Eng Med Biol Proc - "Conference code: 69200" - "Cited By (since 1996): 1" - "Export Date: 4 June 2012" - "Art. No.: 4029784" - "CODEN: CEMBA" - 30 August 2006 through 3 September 2006 - "Source: Scopus"

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