Postradiation fractures after combined modality treatment in extremity soft tissue sarcomas Review

   


Authors: Bartelstein, M. K.; Yerramilli, D.; Christ, A. B.; Kenan, S.; Ogura, K.; Fujiwara, T.; Fabbri, N.; Healey, J. H.
Review Title: Postradiation fractures after combined modality treatment in extremity soft tissue sarcomas
Abstract: Soft tissue sarcoma (STS) of the extremities is typically treated with limb-sparing surgery and radiation therapy; with this treatment approach, high local control rates can be achieved. However, postradiation bone fractures, fractures occurring in the prior radiation field with minimal or no trauma, are a serious late complication that occurs in 2-22% of patients who receive surgery and radiation for STS. Multiple risk factors for sustaining a postradiation fracture exist, including high radiation dose, female sex, periosteal stripping, older age, femur location, and chemotherapy administration. The treatment of these pathological fractures can be difficult, with complications including delayed union, nonunion, and infection posing particular challenges. Here, we review the mechanisms, risk factors, and treatment challenges associated with postradiation fractures in STS patients. © 2021 Meredith K. Bartelstein et al.
Journal Title: Sarcoma
Volume: 2021
ISSN: 1357-714X
Publisher: Hindawi Publishing Corporation  
Date Published: 2021-03-15
Start Page: 8877567
Language: English
DOI: 10.1155/2021/8877567
PROVIDER: scopus
PMCID: PMC7984930
PUBMED: 33790687
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103576224&doi=10.1155%2f2021%2f8877567&partnerID=40&md5=ed270d57bfdacefe73e0c2c5872e0158
Notes: Article -- Export Date: 3 May 2021 -- Source: Scopus
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MSK Authors
  1. John H Healey
    547 Healey
  2. Nicola Fabbri
    64 Fabbri
  3. Shachar Kenan
    4 Kenan
  4. Alexander Bryant Christ
    11 Christ
  5. Koichi Ogura
    15 Ogura
  6. Tomohiro Fujiwara
    17 Fujiwara
  7. Divya Yerramilli
    49 Yerramilli
  8. Meredith Bartelstein
    23 Bartelstein
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