Platelet-derived growth factor (PDGF) and glial tumorigenesis Journal Article
| Authors: | Shih, A. H.; Holland, E. C. |
| Article Title: | Platelet-derived growth factor (PDGF) and glial tumorigenesis |
| Abstract: | Platelet-derived growth factor (PDGF) has long been implicated in cancer and is known to be involved in many biological processes. In Central Nervous System (CNS) neoplasms, particularly gliomas, PDGF is often over-expressed. However, what role PDGF plays in tumor progression remains to be fully described. A wide range of work from in vitro studies to mouse models have implicated the PDGF pathway in various processes including proliferation, cellular migration, development, and angiogenesis. Being a secreted factor, PDGF not only has autocrine effects on producing cells but also has potential for paracrine effects on other tumor cells and the tumor microenvironment. The development of small molecules that inhibit the PDGF receptor and various subsequent signaling components promises to introduce new approaches to the treatment of gliomas. © 2005 Elsevier Ireland Ltd. All rights reserved. |
| Keywords: | signal transduction; platelet derived growth factor; protein expression; nonhuman; glioma; protein function; cell proliferation; animals; platelet derived growth factor alpha receptor; gene expression; cell maturation; cell differentiation; enzyme activity; platelet derived growth factor receptor; angiogenesis; central nervous system tumor; central nervous system; carcinogenesis; platelet-derived growth factor; autocrine effect; cell migration; short survey; tumor growth; receptors, platelet-derived growth factor; platelet derived growth factor beta receptor; oligodendroglia; gliomas; platelet derived growth factor a |
| Journal Title: | Cancer Letters |
| Volume: | 232 |
| Issue: | 2 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 2006-02-08 |
| Start Page: | 139 |
| End Page: | 147 |
| Language: | English |
| DOI: | 10.1016/j.canlet.2005.02.002 |
| PUBMED: | 16139423 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 68" - "Export Date: 4 June 2012" - "CODEN: CALED" - "Source: Scopus" |
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