Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors Journal Article
| Authors: | Shaked, Y.; Ciarrocchi, A.; Franco, M.; Lee, C. R.; Man, S.; Cheung, A. M.; Hicklin, D. J.; Chaplin, D.; Foster, F. S.; Benezra, R.; Kerbel, R. S. |
| Article Title: | Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors |
| Abstract: | The contribution of bone marrow-derived circulating endothelial progenitor cells (CEPs) to tumor angiogenesis has been controversial, primarily because of their low numbers in blood vessels of untreated tumors. We show that treatment of tumor-bearing mice with vascular disrupting agents (VDAs) leads to an acute mobilization of CEPs, which home to the viable tumor rim that characteristically remains after such therapy. Disruption of this CEP spike by antiangiogenic drugs or by genetic manipulation resulted in marked reductions in tumor rim size and blood flow as well as enhanced VDA antitumor activity. These findings also provide a mechanistic rationale for the enhanced efficacy of VDAs when combined with antiangiogenic drugs. |
| Keywords: | controlled study; nonhuman; animal cell; mouse; animals; mice; animal tissue; bone marrow cells; genes; tumor volume; antineoplastic combined chemotherapy protocols; animal model; antineoplastic agents, phytogenic; antineoplastic activity; cell line, tumor; angiogenesis; neovascularization, pathologic; necrosis; cancer therapy; mice, inbred c57bl; genetic manipulation; stem cell; endothelial cells; antibodies, monoclonal; mice, nude; tumors; neoplasms, experimental; stem cells; cell hypoxia; neoplasm transplantation; tumor; drug therapy; angiogenesis inhibitors; vascular targeting agent; blood vessels; biomedical engineering; cells; cells and cell components; stilbenes; antiangiogenic drugs; circulating endothelial progenitor cells (cep); vascular disrupting agents (vda); diphosphates |
| Journal Title: | Science |
| Volume: | 313 |
| Issue: | 5794 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2006-09-01 |
| Start Page: | 1785 |
| End Page: | 1787 |
| Language: | English |
| DOI: | 10.1126/science.1127592 |
| PUBMED: | 16990548 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 256" - "Export Date: 4 June 2012" - "CODEN: SCIEA" - "Source: Scopus" |
