Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: Implications for antiangiogenic drugs as chemosensitizing agents Journal Article
| Authors: | Shaked, Y.; Henke, E.; Roodhart, J. M. L.; Mancuso, P.; Langenberg, M. H. G.; Colleoni, M.; Daenen, L. G.; Man, S.; Xu, P.; Emmenegger, U.; Tang, T.; Zhu, Z.; Witte, L.; Strieter, R. M.; Bertolini, F.; Voest, E. E.; Benezra, R.; Kerbel, R. S. |
| Article Title: | Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: Implications for antiangiogenic drugs as chemosensitizing agents |
| Abstract: | Several hypotheses have been proposed to explain how antiangiogenic drugs enhance the treatment efficacy of cytotoxic chemotherapy, including impairing the ability of chemotherapy-responsive tumors to regrow after therapy. With respect to the latter, we show that certain chemotherapy drugs, e.g., paclitaxel, can rapidly induce proangiogenic bone marrow-derived circulating endothelial progenitor (CEP) mobilization and subsequent tumor homing, whereas others, e.g., gemcitabine, do not. Acute CEP mobilization was mediated, at least in part, by systemic induction of SDF-1α and could be prevented by various procedures such as treatment with anti-VEGFR2 blocking antibodies or paclitaxel treatment in CEP-deficient Id mutant mice, both of which resulted in enhanced antitumor effects mediated by paclitaxel, but not by gemcitabine. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; controlled study; vascular endothelial growth factor a; human cell; drug tolerability; angiogenesis inhibitor; cisplatin; doxorubicin; fluorouracil; drug efficacy; nonhuman; antineoplastic agents; capecitabine; gemcitabine; paclitaxel; neoplasms; cell proliferation; mouse; animals; mice; animal tissue; bone marrow cells; mus; carboplatin; apoptosis; ovary cancer; breast cancer; animal experiment; animal model; cyclophosphamide; cytotoxicity; vasculotropin receptor 2; breast neoplasms; mice, inbred balb c; mice, inbred c57bl; vinblastine; docetaxel; irinotecan; sarcoma; endothelial cells; antibodies, monoclonal; drug therapy, combination; tumor burden; stem cell mobilization; melanoma, experimental; stem cells; epirubicin; cellcycle; esophagus cancer; deoxycytidine; angiogenesis inhibitors; chemokine cxcl12; chemosensitization; blocking antibody; carcinoma, lewis lung; monoclonal antibody dc101; stromal cell derived factor 1alpha |
| Journal Title: | Cancer Cell |
| Volume: | 14 |
| Issue: | 3 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2008-09-09 |
| Start Page: | 263 |
| End Page: | 273 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2008.08.001 |
| PUBMED: | 18772115 |
| PROVIDER: | scopus |
| PMCID: | PMC2565587 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 110" - "Export Date: 17 November 2011" - "CODEN: CCAEC" - "Source: Scopus" |
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