Molecular targeting of the lymphovascular system for imaging and therapy Journal Article
| Authors: | Schoder, H.; Glass, E. C.; Pecking, A. P.; Harness, J. K.; Wallace, A. M.; Hirnle, P.; Alberini, J. L.; Vilain, D.; Larson, S. M.; Hoh, C. K.; Vera, D. R. |
| Article Title: | Molecular targeting of the lymphovascular system for imaging and therapy |
| Abstract: | Progress toward targeting cancer cells is a multi-disciplinary endeavor. In addition to the surgical and oncology specialties, radiologists collaborate with mathematicians, computer scientists, and physicists, in a constant effort to incrementally improve upon the current imaging modalities. Recently, radiologists have formed collaborations with molecular biologists and chemists in order to develop molecular agents that target cancer cells via receptor-substrate or specific physiochemical interactions. In this review, we summarize selected efforts toward molecular targeting of the lymphovascular system. Standard imaging modalities, positron emission tomography, single photon emission tomography, and ultrasound, are reviewed as well as, the targeted introduction of substances for endolymphatic therapy. We also review the current status of sentinel lymph node mapping with radiocolloids and the application of molecular targeting for the development of a radiopharmaceutical specifically designed for sentinel lymph node mapping. © Springer Science + Business Media, LLC 2006. |
| Keywords: | unclassified drug; clinical trial; nonhuman; conference paper; drug targeting; radiation dose; positron emission tomography; recurrent cancer; cancer diagnosis; lymph nodes; lymphatic metastasis; sentinel lymph node mapping; sentinel lymph node; clinical practice; neoplasms; colorectal cancer; lymphadenectomy; cell proliferation; animals; melanoma; metastasis; breast cancer; diagnostic imaging; angiogenesis; radiation injury; tumor marker; cancer therapy; ultrasound; hodgkin disease; carcinogenesis; monoclonal antibody; hypoxia; lymph vessel; lymphatic system; molecular mechanics; drug distribution; isotope labeling; head and neck cancer; tumor recurrence; cancer cell; echography; lymphoma; fluorodeoxyglucose f 18; positron-emission tomography; radiopharmaceutical agent; cell migration; drug clearance; bleomycin; cholesterol; 1 fluoro 3 (2 nitro 1 imidazolyl) 2 propanol f 18; safety; tracer; drug half life; molecular biology; testis cancer; pet; radiodiagnosis; tumor diagnosis; liposome; phosphatidylcholine; cytostatic agent; tomography, emission-computed, single-photon; technetium sulfur colloid tc 99m; glucose metabolism; colloid; lymphography; clinical trials, phase i; image fusion; endolymphatic therapy; molecular targeting; fructose 2,6 bisphosphate; iron derivative; iron ferrumoxtran; lymphoseek; glucose-6-phosphate |
| Journal Title: | Cancer and Metastasis Reviews |
| Volume: | 25 |
| Issue: | 2 |
| ISSN: | 0167-7659 |
| Publisher: | Springer |
| Date Published: | 2006-06-01 |
| Start Page: | 185 |
| End Page: | 201 |
| Language: | English |
| DOI: | 10.1007/s10555-006-8498-0 |
| PUBMED: | 16770532 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 4 June 2012" - "CODEN: CMRED" - "Source: Scopus" |
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