Update on epidermal growth factor receptor mutations in non-small cell lung cancer Journal Article
| Authors: | Riely, G. J.; Politi, K. A.; Miller, V. A.; Pao, W. |
| Article Title: | Update on epidermal growth factor receptor mutations in non-small cell lung cancer |
| Abstract: | In 2004, several investigators reported that somatic mutations in the epidermal growth factor receptor gene were associated with clinical responses to erlotinib and gefitinib in patients with non - small cell lung cancer. Since then, multiple groups have examined the biological properties that such mutations confer as well as the clinical relevance of these mutations in patients with non - small cell lung cancer. Although a tremendous amount of knowledge has been gained in the past 2 years, there remain a number of important epidemiologic, biological, and clinical questions. © 2006 American Association for Cancer Research. |
| Keywords: | cancer survival; treatment response; somatic mutation; mutation; clinical trial; review; erlotinib; paclitaxel; carboplatin; gene amplification; models, biological; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; epidermal growth factor receptor; cell line; gene frequency; lung cancer; receptor, epidermal growth factor; drug resistance; drug resistance, neoplasm; mutational analysis; wild type; oncogene; gefitinib; gene duplication |
| Journal Title: | Clinical Cancer Research |
| Volume: | 12 |
| Issue: | 24 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2006-12-15 |
| Start Page: | 7232 |
| End Page: | 7241 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-06-0658 |
| PUBMED: | 17189394 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 145" - "Export Date: 4 June 2012" - "CODEN: CCREF" - "Source: Scopus" |
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