Association between urinary cytology and pathology for nontransitional cell malignancies of the urinary tract Journal Article


Authors: Raj, G. V.; Bochner, B. H.; Vickers, A.; Teper, E.; Lin, O.; Donat, S. M.; Herr, H.; Dalbagni, G.
Article Title: Association between urinary cytology and pathology for nontransitional cell malignancies of the urinary tract
Abstract: Purpose: Because nontransitional cell carcinoma neoplasms of the urinary tract are rare in Western countries, we examined the association between urinary cytology and pathology evaluations for these tumors. Materials and Methods: An institutional review board approved, retrospective review of a total of 55,946 cytology evaluations in 12,705 patients between 1992 and 2004 was performed for correlation with subsequent histopathology findings. Documented urothelial neoplasms were then correlated with previous cytology results. Nontransitional cell carcinomas were categorized as adenocarcinoma, squamous cell carcinoma and other, including small cell disease, sarcoma, melanoma or lymphoma. Results: All 108 patients with cytology evaluations showing adenocarcinoma had histological evidence of cancer and 86% had adenocarcinoma in the urinary tract. All 110 patients with squamous cell carcinoma on cytology had cancer, including 47% with primary squamous cell disease. All 42 patients with other nontransitional cell carcinomas on cytology evaluation had cancer, of whom 64% had histological concordance. In a separate analysis of 70 patients who had pathologically confirmed adenocarcinoma 57% had positive prior cytology findings, of whom 19% had histological concordance. Of 85 patients with squamous cell carcinoma 81% had positive prior cytology findings, of whom 60% had histological concordance. Of 83 patients with other nontransitional cell carcinomas 70% had positive prior cytology findings, of whom 31% had histological concordance. Conclusions: In our series all patients with nontransitional cell carcinoma cytological results had cancer in the urinary tract. Thus, nontransitional cell carcinoma cytology findings mandate careful urinary tract evaluation. Concordance with histological subclassification on subsequent pathology evaluation ranges from 49% for squamous cell carcinoma to 86% for adenocarcinoma. A majority of patients with nontransitional cell carcinoma malignancies had positive prior cytology findings. However, the concordance with histological subclassification on prior cytology results ranges from 19% for adenocarcinoma to 60% for squamous cell carcinoma. © 2006 American Urological Association.
Keywords: adolescent; adult; child; controlled study; aged; aged, 80 and over; child, preschool; middle aged; retrospective studies; human cell; major clinical study; histopathology; squamous cell carcinoma; cancer patient; adenocarcinoma; reproducibility of results; cytology; melanoma; patient assessment; retrospective study; sarcoma; urologic neoplasms; correlation analysis; infant; diagnosis; lymphoma; urinary tract cancer; carcinoma; urine; urogenital tract tumor; medical documentation; urinary tract carcinoma; cytopathology; transitional cell; urinary tract; urine cytology
Journal Title: Journal of Urology
Volume: 175
Issue: 6
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 2006-06-01
Start Page: 2038
End Page: 2041
Language: English
DOI: 10.1016/s0022-5347(06)00279-5
PUBMED: 16697796
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 4 June 2012" - "CODEN: JOURA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Ganesh Raj
    20 Raj
  2. Guido Dalbagni
    253 Dalbagni
  3. Sherri M Donat
    135 Donat
  4. Oscar Lin
    231 Lin
  5. Andrew J Vickers
    565 Vickers
  6. Bernard Bochner
    327 Bochner
  7. Harry W Herr
    407 Herr
  8. Ervin Teper
    1 Teper