ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression Journal Article
| Authors: | Peduto, L.; Reuter, V. E.; Sehara-Fujisawa, A.; Shaffer, D. R.; Scher, H. I.; Blobel, C. P. |
| Article Title: | ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression |
| Abstract: | The interaction between stromal cells and tumor cells is emerging as a critical aspect of tumor progression. Yet there is a paucity of molecular markers for cells participating in such interactions, and only few genes are known to play a critical role in this process. Here, we describe the identification of ADAM12 (a disintegrin and metalloprotease 12) as a novel marker for a subpopulation of stromal cells that are adjacent to epithelial tumor cells in three mouse carcinoma models (models for prostate, breast and colon cancer). Moreover, we show that ADAM12 is essential for tumor development and progression in the W10 mouse model for prostate cancer. These results suggest that ADAM12 might be a useful marker for stromal cells in mouse tumors that are likely to participate in stromal/tumor cell crosstalk, and that ADAM12 is a potential target for design of drugs that prevent carcinoma growth. © 2006 Nature Publishing Group. All rights reserved. |
| Keywords: | protein expression; unclassified drug; nonhuman; antineoplastic agents; protein analysis; mouse; animals; mice; cell division; tumor marker; prostate cancer; prostatic neoplasms; alpha smooth muscle actin; gene expression regulation, neoplastic; disease progression; prostate tumor; breast carcinoma; membrane protein; cell subpopulation; tumor cell; upregulation; tumor growth; colon carcinoma; stroma cell; intestinal neoplasms; stromal cells; cell interaction; breast carcinogenesis; epithelium tumor; metalloproteinase; adam proteins; prostate carcinoma; intestine carcinoma; mammary neoplasms, animal; metalloprotease-disintegrin; adam12; stromal/tumor cell interaction; a disintegrin and metalloprotease 12 |
| Journal Title: | Oncogene |
| Volume: | 25 |
| Issue: | 39 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2006-08-31 |
| Start Page: | 5462 |
| End Page: | 5466 |
| Language: | English |
| DOI: | 10.1038/sj.onc.1209536 |
| PUBMED: | 16607276 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 35" - "Export Date: 4 June 2012" - "CODEN: ONCNE" - "Source: Scopus" |
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