Hypermethylation of CpG island in the promoter region of CALCA in acute lymphoblastic leukemia with central nervous system (CNS) infiltration correlates with poorer prognosis Journal Article
| Authors: | Paixão, V. A.; Vidal, D. O.; Caballero, O. L.; Vettore, A. L.; Tone, L. G.; Ribeiro, K. B.; Lopes, L. F. |
| Article Title: | Hypermethylation of CpG island in the promoter region of CALCA in acute lymphoblastic leukemia with central nervous system (CNS) infiltration correlates with poorer prognosis |
| Abstract: | Promoter hypermethylation occurs early in leukemogenesis and seems to be associated with poor prognosis in acute lymphoblastic leukemia (ALL). The methylation status of the promoter region of six genes was analyzed in 71 children with ALL using methylation specific PCR (MSP). Calcitonin (CALCA) and E-cadherin (CDH1) were the most frequently methylated genes in this group of patients. Considering the patients with central nervous system (CNS) infiltration, the estimated 2-year overall survival (OS) was 20% for those with methylation in CALCA promoter and 85% for those without (p = 0.001). Our results suggest that the hypermethylation of CALCA promoter is a promising prognostic marker and may predict a higher risk for ALL patients with CNS infiltration. © 2006 Elsevier Ltd. All rights reserved. |
| Keywords: | survival; child; controlled study; leukemia; survival rate; human cell; major clinical study; methylation; promoter region; sensitivity and specificity; genetic analysis; polymerase chain reaction; gene expression; risk factors; calcitonin; dna methylation; prediction; acute lymphoblastic leukemia; high risk patient; central nervous system; central nervous system neoplasms; kaplan-meiers estimate; correlation analysis; cpg island; cpg islands; cns; all; promoter regions (genetics); leukemia, lymphocytic, acute, l1; msp; calca |
| Journal Title: | Leukemia Research |
| Volume: | 30 |
| Issue: | 7 |
| ISSN: | 0145-2126 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2006-07-01 |
| Start Page: | 891 |
| End Page: | 894 |
| Language: | English |
| DOI: | 10.1016/j.leukres.2005.11.016 |
| PUBMED: | 16712930 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 4 June 2012" - "CODEN: LERED" - "Source: Scopus" |
