Methylation profile of genes CDKN2A (p14 and p16), DAPK1, CDH1, and ADAM23 in head and neck cancer Journal Article
| Authors: | Calmon, M. F.; Colombo, J.; Carvalho, F.; Souza, F. P.; Filho, J. F. G.; Fukuyama, E. E.; Camargo, A. A.; Caballero, O. L. S.; Tajara, E. H.; Cordeiro, J. A.; Rahal, P. |
| Article Title: | Methylation profile of genes CDKN2A (p14 and p16), DAPK1, CDH1, and ADAM23 in head and neck cancer |
| Abstract: | Hypermethylation in the promoter region has been associated with a loss of gene function that may give a selective advantage to neoplastic cells. In this study, the methylation pattern of genes CDKN2A (alias p14, p14ARF, p16, p16INK4a), DAPK1, CDH1, and ADAM23 was analyzed in 43 samples of head and neck tumors using methylation-specific polymerase chain reaction. In the oropharynx, there was a statistically significant association between hypermethylation of the DAPK1 gene and the occurrence of lymph node metastases, and in the larynx there was statistically significant evidence of an association between hypermethylation of the ADAM23 gene and advanced stages of the tumors. Thus, a correlation was observed between hypermethylation of the promoter region of genes DAPK1 and ADAM23 and the progression of head and neck cancer. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | adult; controlled study; human tissue; aged; aged, 80 and over; middle aged; unclassified drug; methylation; promoter region; advanced cancer; cancer growth; lymph node metastasis; genetic analysis; polymerase chain reaction; protein p16; apoptosis regulatory proteins; hct116 cells; cell line, tumor; uvomorulin; dna methylation; cancer genetics; correlation analysis; head and neck cancer; head and neck neoplasms; dna, neoplasm; oropharynx cancer; cyclin dependent kinase inhibitor 2a; cyclin-dependent kinase inhibitor p16; cyclin dependent kinase inhibitor; cadherins; larynx cancer; mouth cancer; protein p14; adam protein; adam proteins; alias; promoter regions (genetics); adam23 protein; death associated protein kinase; death associated protein kinase 1; ca(2+)-calmodulin dependent protein kinase |
| Journal Title: | Cancer Genetics and Cytogenetics |
| Volume: | 173 |
| Issue: | 1 |
| ISSN: | 0165-4608 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2007-02-01 |
| Start Page: | 31 |
| End Page: | 37 |
| Language: | English |
| DOI: | 10.1016/j.cancergencyto.2006.09.008 |
| PUBMED: | 17284367 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 19" - "Export Date: 17 November 2011" - "CODEN: CGCYD" - "Source: Scopus" |
