Clarifying the mechanics of DNA strand exchange in meiotic recombination Journal Article
| Authors: | Neale, M. J.; Keeney, S. |
| Article Title: | Clarifying the mechanics of DNA strand exchange in meiotic recombination |
| Abstract: | During meiosis, accurate separation of maternal and paternal chromosomes requires that they first be connected to one another through homologous recombination. Meiotic recombination has many intriguing but poorly understood features that distinguish it from recombination in mitotically dividing cells, and several of these features depend on the meiosis-specific DNA strand exchange protein Dmc1 (disrupted meiotic cDNA1). Many questions about this protein have arisen since its discovery more than a decade ago, but recent genetic and biochemical breakthroughs promise to shed light on the unique behaviours and functions of this central player in the remarkable chromosome dynamics of meiosis. © 2006 Nature Publishing Group. |
| Keywords: | unclassified drug; genetics; dna-binding proteins; review; nonhuman; proteins; chromosome; dna recombination; cytology; meiosis; animals; cell cycle proteins; protein; dna; genetic engineering; models, genetic; sequence homology, nucleic acid; adenosine triphosphatases; chromosomes; recombination; crossing over, genetic; meiotic recombination; reca protein; dna strand; homology; biomechanics; deoxyribonucleoprotein; chromosome dynamics; disrupted meiotic cdna1 protein; hop2 protein; mei5 protein; mnd1 protein; rdh54 protein; sae3 protein; maternal effect; paternal effect |
| Journal Title: | Nature |
| Volume: | 442 |
| Issue: | 7099 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2006-07-13 |
| Start Page: | 153 |
| End Page: | 158 |
| Language: | English |
| DOI: | 10.1038/nature04885 |
| PUBMED: | 16838012 |
| PROVIDER: | scopus |
| PMCID: | PMC5607947 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 104" - "Export Date: 4 June 2012" - "CODEN: NATUA" - "Source: Scopus" |
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