Thioredoxin in cancer-Role of histone deacetylase inhibitors Journal Article
| Author: | Marks, P. A. |
| Article Title: | Thioredoxin in cancer-Role of histone deacetylase inhibitors |
| Abstract: | Increased levels of thioredoxin (Trx) occur in a number of human cancers, which may contribute to the resistance of cancers to therapy by scavenging reactive oxygen species (ROS) which are generated by various anti-cancer agents. Many human cancers have low levels of thioredoxin-binding protein (TBP-2). TBP-2 binds to Trx and blocks its reducing activity. Histone deacetylase inhibitors (HDACi) up-regulate TBP-2 in various transformed cells, associated with a decrease in Trx levels. Up-regulation of TBP-2 and decrease of Trx may contribute to the sensitivity of many hematologic and solid tumors to anti-cancer activity of HDACi. © 2006 Elsevier Ltd. All rights reserved. |
| Keywords: | vasculotropin; protein expression; histone deacetylase inhibitor; drug tolerability; review; doxorubicin; cancer growth; disease marker; cancer patient; neoplasms; colorectal cancer; cell proliferation; protein blood level; cell death; lung non small cell cancer; protein stability; antineoplastic activity; cancer cell culture; drug structure; drug selectivity; angiogenesis; cancer resistance; digestive system cancer; cancer inhibition; b cell lymphoma; cytokine; drug mechanism; enzyme inhibitors; colon cancer; histone deacetylase inhibitors; cell migration; reactive oxygen metabolite; cell cycle arrest; binding protein; gene control; down regulation; antioxidant activity; structure analysis; pheochromocytoma; malignant transformation; hypoxia inducible factor 1alpha; t cell leukemia; histone deacetylases; drug binding; histone deacetylase; hypoxia inducible factor 1; suberoylanilide hydroxamic acid; thioredoxin; thioredoxin-binding proteins |
| Journal Title: | Seminars in Cancer Biology |
| Volume: | 16 |
| Issue: | 6 |
| ISSN: | 1044-579X |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2006-12-01 |
| Start Page: | 436 |
| End Page: | 443 |
| Language: | English |
| DOI: | 10.1016/j.semcancer.2006.09.005 |
| PUBMED: | 17095247 |
| PROVIDER: | scopus |
| PMCID: | PMC2766865 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 19" - "Export Date: 4 June 2012" - "CODEN: SECBE" - "Source: Scopus" |
