Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions Journal Article
| Author: | Marks, P. A. |
| Article Title: | Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions |
| Abstract: | There are eleven zinc dependent histone deacetylases (HDAC) in humans which have histones and many non-histone substrates. The substrates of these enzymes include proteins that have a role in regulation of gene expression, cell proliferation, cell migration, cell death, immune pathways and angiogenesis. Inhibitors of HDACs (HDACi) have been developed which alter the structure and function of these proteins, causing molecular and cellular changes that induce transformed cell death. The HDACi are being developed as anti-cancer drugs and have therapeutic potential for many non-oncologic diseases. © 2010 Elsevier B.V. |
| Keywords: | treatment response; histone deacetylase inhibitor; clinical trial; fatigue; review; cisplatin; cancer combination chemotherapy; diarrhea; nonhuman; solid tumor; antineoplastic agents; gemcitabine; paclitaxel; protein function; neoplasm; cell proliferation; animals; cell death; dna damage; cell function; disease association; gene overexpression; protein bcl 2; metastasis; apoptosis; bortezomib; proteasome inhibitor; gene expression; etoposide; lung non small cell cancer; nausea; thrombocytopenia; dehydration; inflammation; genetic transcription; antineoplastic activity; structure-activity relationship; angiogenesis; docetaxel; digestive system cancer; gene expression regulation; cutaneous t cell lymphoma; colon cancer; death receptor; lymphoma; vorinostat; histone deacetylase inhibitors; cell migration; reactive oxygen metabolite; cell movement; cell cycle arrest; epirubicin; 5 aza 2' deoxycytidine; cell cycle g2 phase; down regulation; immunity; protein structure; memory disorder; autophagy; dna topoisomerase (atp hydrolysing); autoimmune disease; neovascularization, physiologic; floxuridine; n (2 aminophenyl) 4 [4 (3 pyridinyl) 2 pyrimidinylaminomethyl]benzamide; panobinostat; romidepsin; histone deacetylases; mouth cancer; cell cycle g1 phase; oxidation reduction reaction; azacitidine; valproic acid; histone deacetylase; pivaloyloxymethyl butyrate; belinostat; butyric acid; epothilone b; central nervous system disease; mechanism of action; malaria; receptor upregulation; dna double strand break; hdac inhibitor; suberoylanilide hydroxamic acid; ellipticine; givinostat; pharmacological biomarker; glucose utilization; mitosis inhibition |
| Journal Title: | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms |
| Volume: | 1799 |
| Issue: | 10 |
| ISSN: | 1874-9399 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2010-10-01 |
| Start Page: | 717 |
| End Page: | 725 |
| Language: | English |
| DOI: | 10.1016/j.bbagrm.2010.05.008 |
| PUBMED: | 20594930 |
| PROVIDER: | scopus |
| PMCID: | PMC4043339 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Source: Scopus" |
