Infiltrative MRI pattern and incomplete initial surgery compromise local control of myxofibrosarcoma Journal Article
| Authors: | Manoso, M. W.; Pratt, J.; Healey, J. H.; Boland, P. J.; Athanasian, E. A. |
| Article Title: | Infiltrative MRI pattern and incomplete initial surgery compromise local control of myxofibrosarcoma |
| Abstract: | Myxofibrosarcoma (MFS) has a high local failure rate of up to 79%. We conducted a retrospective analysis on all patients with the diagnosis of myxofibrosarcoma seen between 1990 and 2004 to assess whether improved imaging with MRI reduced local recurrence, increased survival, and whether radiotherapy following resection influenced outcome. Twenty-one patients were treated for MFS with a median followup of 52 months (range, 18-122). All patients were surgically treated, with 19 receiving limb-sparing surgery. All patients with high grade disease, positive margins, or a prereferral procedure received radiation therapy. The local recurrence rate was 57% for patients with a prior outside procedure (8 of 14), while patients with no prior surgery had a rate of 14% (1 of 7). Prior marginal excision and diffuse fascial spread on MRI predicted an increased local recurrence rate. The disease-free survival at 5 years was 43% (SE, 22%) for low-grade disease and 39% (SE, 18%) for high- grade disease. Magnetic resonance imaging observations suggest a unique pattern of diffuse spread along fascial planes that could be responsible for the high local recurrence. Radiation did not compensate for positive margins, nor did it reduce recurrence after negative margins. © 2006 Lippincott Williams & Wilkins. |
| Keywords: | adult; cancer survival; clinical article; human tissue; aged; bone neoplasms; disease-free survival; middle aged; bone tumor; limb salvage; retrospective studies; histopathology; mortality; cancer recurrence; multimodality cancer therapy; conference paper; adjuvant therapy; cancer radiotherapy; disease free survival; combined modality therapy; radiotherapy, adjuvant; nuclear magnetic resonance imaging; magnetic resonance imaging; neoplasm recurrence, local; pathology; retrospective study; fibrosarcoma; tumor recurrence; soft tissue sarcoma |
| Journal Title: | Clinical Orthopaedics and Related Research |
| Volume: | 450 |
| ISSN: | 0009-921X |
| Publisher: | Springer |
| Date Published: | 2006-09-01 |
| Start Page: | 89 |
| End Page: | 94 |
| Language: | English |
| DOI: | 10.1097/01.blo.0000229292.98850.14 |
| PUBMED: | 16801862 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 9" - "Export Date: 4 June 2012" - "CODEN: CORTB" - "Source: Scopus" |
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9Manoso -
547Healey -
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