Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: Report of two cases Journal Article
| Authors: | Leonard, G. D.; Kemeny, N. E. |
| Article Title: | Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: Report of two cases |
| Abstract: | The treatment of metastatic colorectal cancer by chemotherapy alone was considered palliative and without the potential to cure patients unless patients were rendered resectable. We report two patients with metastatic colorectal cancer involving the liver who were considered inoperable and were treated with systemic chemotherapy using biomodulated 5-fluorouracil. Both patients received 5-fluorouracil and N-(phosphonoacetyl)-l-aspartic acid; one also received methotrexate, leucovorin, and triacetyluridine with the N-(phosphonoacetyl)-l- aspartic acid and 5-fluorouracil. Both patients had a complete remission with chemotherapy and are still alive with no evidence of cancer ten years after the diagnosis of unresectable metastatic disease. These patients provide evidence that prolonged survival can be achieved withsystemic chemotherapy without the use of surgery or other forms of local therapy. These patients also confirm the importance of continued investigation of fluorouracil modulating agents, which may further enhance the recent progress made with fluorouracil-based combination chemotherapy for colorectal cancer. © The American Society of Colon and Rectal Surgeons. |
| Keywords: | survival; adult; cancer chemotherapy; cancer survival; aged; middle aged; unclassified drug; case report; fluorouracil; liver neoplasms; chemotherapy; methotrexate; antineoplastic agent; cancer palliative therapy; colorectal cancer; metastasis; antineoplastic combined chemotherapy protocols; colorectal neoplasms; liver metastasis; cancer regression; colonoscopy; folinic acid; remission induction; liver resection; hemicolectomy; leucovorin; aspartic acid; vitamin b complex; uridine; phosphonoacetic acid; metastatic colorectal cancer; biological response modifiers; iron deficiency anemia; biomodulation; sparfosic acid; triacetyluridine |
| Journal Title: | Diseases of the Colon and Rectum |
| Volume: | 49 |
| Issue: | 3 |
| ISSN: | 0012-3706 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2006-03-01 |
| Start Page: | 407 |
| End Page: | 410 |
| Language: | English |
| DOI: | 10.1007/s10350-005-0278-3 |
| PUBMED: | 16475032 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 4 June 2012" - "CODEN: DICRA" - "Source: Scopus" |
