Clinical manifestations and treatment of newly diagnosed acute lymphoblastic leukemia in adults Journal Article
| Authors: | Landau, H.; Lamanna, N. |
| Article Title: | Clinical manifestations and treatment of newly diagnosed acute lymphoblastic leukemia in adults |
| Abstract: | Adult acute lymphoblastic leukemia (ALL) is a heterogeneous disease with distinct biologic and prognostic subgroups. The treatment of adults with ALL has evolved largely from the therapy developed for childhood ALL and, despite differences across regimens, can be broadly classified as including induction, consolidation, maintenance, and central nervous system prophylaxis. Although there has been marked improvement in the outcomes for pediatric patients with ALL, the same success has not yet been realized for adult patients. Some of this difference can be attributed to a greater incidence of unfavorable cytogenetic subtypes in adults than in children. In addition, the ability to tolerate intensive regimens likely plays a role. This article reviews the classification, prognostic features, current treatment programs, and new advances as applied to adult patients with newly diagnosed ALL. Copyright © 2006 by Current Science Inc. |
| Keywords: | adult; child; prednisone; allogeneic stem cell transplantation; clinical feature; clinical trial; review; doxorubicin; clinical trials as topic; cytarabine; genetic analysis; polymerase chain reaction; t lymphocyte; antineoplastic combined chemotherapy protocols; incidence; cyclophosphamide; vincristine; hematopoietic stem cell transplantation; central nervous system; cranial irradiation; b lymphocyte; acute leukemia; minimal residual disease; neoplasm, residual; prophylaxis; mitoxantrone; remission induction; asparaginase; glucocorticoid; precursor cell lymphoblastic leukemia-lymphoma; translocation, genetic; immunophenotyping; anthracycline; testis; burkitt lymphoma; eye; lymphocyte subsets; leukemic infiltration |
| Journal Title: | Current Hematologic Malignancy Reports |
| Volume: | 1 |
| Issue: | 3 |
| ISSN: | 1558-8211 |
| Publisher: | Springer |
| Date Published: | 2006-07-01 |
| Start Page: | 171 |
| End Page: | 179 |
| Language: | English |
| DOI: | 10.1007/s11899-996-0005-8 |
| PUBMED: | 20425348 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 4 June 2012" - "Source: Scopus" |
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