Harmonization of the upfront osteosarcoma treatment paradigm for adolescents and young adults Journal Article

  


Authors: Daukshus, N. P.; Avutu, V.; Long Sarro, E.; Kinnaman, M. D.; Slotkin, E. K.; Thornton, K.; Dickson, M. A.; Sklarin, N. T.; Tap, W. D.; Glade Bender, J.
Article Title: Harmonization of the upfront osteosarcoma treatment paradigm for adolescents and young adults
Abstract: Limited guidance exists on streamlining cancer therapy for adolescent and young adult (AYA) patients 15-39 years of age, as much of the current data are extrapolated from pediatric or adult counterparts and can differ significantly between the two care models. Harmonization of standard treatment approaches has the potential to improve outcomes and establish a foundation for the development of future clinical trials. We present our experience harmonizing treatment and supportive care regimens for AYA patients with osteosarcoma receiving treatment with methotrexate, doxorubicin, and cisplatin (MAP) therapy on the pediatric and adult sarcoma services at the Memorial Sloan Kettering Cancer Center. Copyright 2025, Mary Ann Liebert, Inc., publishers.
Keywords: osteosarcoma; adolescent; adult; bone neoplasms; bone tumor; young adult; cisplatin; doxorubicin; treatment; methotrexate; antineoplastic agent; antineoplastic combined chemotherapy protocols; pneumocystis pneumonia; practice guideline; kidney function; antiemetic agent; drug therapy; mannitol; outpatient care; therapy; drug use; infusion fluid; razoxane; harmonization; humans; human; male; female; article; adolescent and young adult
Journal Title: Journal of Adolescent and Young Adult Oncology
Volume: 14
Issue: 1
ISSN: 2156-5333
Publisher: Mary Ann Liebert, Inc  
Date Published: 2025-02-01
Start Page: 62
End Page: 67
Language: English
DOI: 10.1089/jayao.2024.0054
PUBMED: 39008434
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199009913&doi=10.1089%2fjayao.2024.0054&partnerID=40&md5=e35e8f8d0b64d7bbd81869f16a179c26
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding MSK author is Nicole P. Daukshus -- Source: Scopus
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MSK Authors
  1. Nancy T Sklarin
    54 Sklarin
  2. Mark Andrew Dickson
    169 Dickson
  3. William Douglas Tap
    372 Tap
  4. Emily Kanaya Slotkin
    65 Slotkin
  5. Michael Kinnaman
    17 Kinnaman
  6. Emily Sarro
    4 Sarro
  7. Julia L Glade Bender
    85 Glade Bender
  8. Viswatej Avutu
    32 Avutu
  9. Katherine Anne Thornton
    31 Thornton
  10. Nicole P Daukshus
    4 Daukshus
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