The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells Journal Article
| Authors: | Lacorazza, H. D.; Yamada, T.; Liu, Y.; Miyata, Y.; Sivina, M.; Nunes, J.; Nimer, S. D. |
| Article Title: | The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells |
| Abstract: | The transcriptional circuitry that regulates the quiescence of hematopoietic stem cells is largely unknown. We report that the transcription factor known as MEF (or ELF4), which is targeted by the t(X;21)(q26;q22) in acute myelogenous leukemia, regulates the proliferation of primitive hematopoietic progenitor cells at steady state, controlling their quiescence. Mef null HSCs display increased residence in G 0 with reduced 5-bromodeoxyuridine incorporation in vivo and impaired cytokine-driven proliferation in vitro. Due to their increased HSC quiescence, Mef null mice are relatively resistant to the myelosuppressive effects of chemotherapy and radiation. Thus, MEF plays an important role in the decision of stem/primitive progenitor cells to divide or remain quiescent by regulating their entry to the cell cycle. © 2006 Elsevier Inc. |
| Keywords: | cancer chemotherapy; controlled study; unclassified drug; acute granulocytic leukemia; dna-binding proteins; busulfan; fluorouracil; nonhuman; cancer radiotherapy; cell proliferation; animal cell; mouse; animals; mice; cells, cultured; drug inhibition; bone marrow suppression; steady state; transcription factor; cell differentiation; cytotoxicity; animalia; transcription factors; stem cell; cytokine; hematopoietic stem cells; single drug dose; hoe 33342; hematopoietic stem cell; bone and bones; bone marrow transplantation; cell cycle g0 phase; broxuridine; antimetabolites; transcription factor elf4 |
| Journal Title: | Cancer Cell |
| Volume: | 9 |
| Issue: | 3 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2006-03-01 |
| Start Page: | 175 |
| End Page: | 187 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2006.02.017 |
| PUBMED: | 16530702 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 58" - "Export Date: 4 June 2012" - "CODEN: CCAEC" - "Source: Scopus" |
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