Advances in biology, diagnostics, and treatment of Hodgkin's disease Journal Article
| Authors: | Küppers, R.; Yahalom, J.; Josting, A. |
| Article Title: | Advances in biology, diagnostics, and treatment of Hodgkin's disease |
| Abstract: | Hodgkin and Reed-Sternberg cells are derived from germinal center B cells. Amplification of identical rearranged and mutated immunoglobulin genes from different Hodgkin and Reed-Sternberg cells from the same patient also answered the question of the malignant nature because the clonality - the key criterion of malignancy - of Hodgkin and Reed-Sternberg cells was hereby shown. In addition, it could be demonstrated that Hodgkin and Reed-Sternberg cells do not only expand clonally within 1 affected lymph node, but also clonally disseminate in advanced-stage disease and relapse even after clinical complete remission. Recent publications demonstrate that a probably small subset of Hodgkin disease exists with T-cell derivation of the respective Hodgkin and Reed-Sternberg cells. The management of Hodgkin's disease is undergoing a paradigm shift as a result of very effective drug regimens that are capable of inducing high remission rates, the use of combined chemoradiotherapy with involved-field irradiation in early stages, the introduction of effective salvage chemotherapy of relapsed Hodgkin's disease with peripheral stem cell transplantation, a better understanding of prognostic factors, economic constraints, and a more sensitive realization of the magnitude of late treatment mortality. © 2006 American Society for Blood and Marrow Transplantation. |
| Keywords: | signal transduction; protein expression; disease-free survival; treatment failure; acute granulocytic leukemia; gene mutation; gene translocation; mutation; prednisone; clinical trial; intensity modulated radiation therapy; salvage therapy; cisplatin; doxorubicin; drug efficacy; drug potentiation; treatment planning; drug targeting; gemcitabine; cancer adjuvant therapy; radiation dose; combined modality therapy; chemotherapy; cytarabine; methotrexate; cancer staging; drug megadose; positron emission tomography; antineoplastic agent; t-lymphocytes; dacarbazine; stat3 protein; unindexed drug; bortezomib; enzyme inhibition; etoposide; radiotherapy; cyclophosphamide; dexamethasone; melphalan; vincristine; antineoplastic activity; protein p53; cancer mortality; carmustine; chlormethine; procarbazine; vinblastine; hodgkin disease; infertility; carcinogenesis; cancer resistance; drug fatality; vincristine sulfate; germinal center; cancer regression; acute leukemia; myelodysplastic syndrome; clonal variation; remission induction; bleomycin; cancer relapse; epirubicin; navelbine; computer assisted radiotherapy; drug dose regimen; peripheral blood stem cell transplantation; granulocyte colony stimulating factor; caspase 10; radiation field; epstein barr virus; economic aspect; bone marrow toxicity; reed sternberg cell; reed-sternberg cells; transcription factor ap 1; transcription factor rel; mantle field radiotherapy; fas associated death domain protein; hodgkin's disease; gene rearrangement, b-lymphocyte; hodgkin and reed-sternberg cells |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 12 |
| Issue: | Suppl.1 |
| ISSN: | 1083-8791 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-01-01 |
| Start Page: | 66 |
| End Page: | 76 |
| Language: | English |
| DOI: | 10.1016/j.bbmt.2005.10.016 |
| PUBMED: | 16399588 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 20" - "Export Date: 4 June 2012" - "CODEN: BBMTF" - "Source: Scopus" |
