Importance of node dissection in relation to neoadjuvant and adjuvant therapy Journal Article
| Authors: | Huang, W. C.; Bochner, B. H. |
| Article Title: | Importance of node dissection in relation to neoadjuvant and adjuvant therapy |
| Abstract: | Since the advent of effective chemotherapeutic regimens for treating transitional cell carcinoma, multimodal therapy has become part of the contemporary management of patients with muscle-invasive bladder cancer. However, radical cystectomy with pelvic lymphadenectomy remains the cornerstone of treatment for patients with localized and regionally advanced muscle-invasive disease. The effectiveness of chemotherapy models in bladder cancer can depend greatly on the quality of surgery. Unfortunately, without sufficient level I data, the boundaries of lymphadenectomy and the diagnostic and therapeutic ramifications of variations in the pelvic lymph node dissection remain undetermined. This article examines the role of pelvic lymph node dissection during perioperative chemotherapy and discusses the current challenges in establishing standards for lymphadenectomy in patients undergoing treatment for muscle-invasive bladder cancer. © Journal of the National Comprehensive Cancer Network. |
| Keywords: | surgical technique; clinical trial; review; cisplatin; doxorubicin; gemcitabine; adjuvant therapy; chemotherapy, adjuvant; neoadjuvant therapy; chemotherapy; methotrexate; cancer staging; antineoplastic agent; lymph node dissection; pelvis lymph node; neoplasm staging; lymph node excision; lymphadenectomy; nephrotoxicity; antineoplastic combined chemotherapy protocols; peripheral neuropathy; bladder cancer; urinary bladder neoplasms; vinblastine; cancer invasion; systematic review; adjuvant chemotherapy; cystectomy; pelvic lymph node dissection; neoplasm invasiveness; perioperative period; carcinoma, transitional cell; bladder carcinoma; transitional cell carcinoma; meta analysis; clinical trials; granulocytopenia |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 4 |
| Issue: | 10 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2006-11-01 |
| Start Page: | 1019 |
| End Page: | 1026 |
| Language: | English |
| PUBMED: | 17112450 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 4 June 2012" - "Source: Scopus" |
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