| Abstract: |
Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both MMTV-Wnt-1 and MMTV-Neu. In this report, gene expression profiles were determined for tumors from these bitransgenic mice, and compared with expression profiles of tumors from mice singly transgenic for MMTV-Wnt-1 or MMTV-Neu. While very different from tumors arising in MMTV-Neu transgenic mice, tumors from these bitransgenic mice were found not to have identifiable differences from tumors from MMTV-Wnt-1 transgenic mice, using clustering and multidimensional scaling analyses (unsupervised and supervised). One-way Analysis of Variance (ANOVA), and two sample t test (the later two of which were combined with false discovery rate computation). These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles. ©Adenine Press (2006). |
| Keywords: |
nonhuman; mouse; animals; mice; cluster analysis; gene expression profiling; epidermal growth factor receptor 2; tumor markers, biological; animal experiment; animal model; breast neoplasms; transgenic mouse; mice, transgenic; oncogene; gene expression regulation, neoplastic; oligonucleotide array sequence analysis; gene identification; breast tumor; receptor, erbb-2; analysis of variance; breast carcinogenesis; wnt1 protein; mouse model; mammary neoplasms, animal; mammary tumor virus, mouse; and breast cancer; neu gene; wnt 1 gene; genes, dominant
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