Cyclin-dependent kinase directly regulates initiation of meiotic recombination Journal Article
| Authors: | Henderson, K. A.; Kee, K.; Maleki, S.; Santini, P. A.; Keeney, S. |
| Article Title: | Cyclin-dependent kinase directly regulates initiation of meiotic recombination |
| Abstract: | Meiosis is a specialized cell division that halves the genome complement, producing haploid gametes/spores from diploid cells. Proper separation of homologous chromosomes at the first meiotic division requires the production of physical connections (chiasmata) between homologs through recombinational exchange of chromosome arms after sister-chromatid cohesion is established but before chromosome segregation takes place. The events of meiotic prophase must thus occur in a strictly temporal order, but the molecular controls coordinating these events have not been well elucidated. Here, we demonstrate that the budding yeast cyclin-dependent kinase Cdc28 directly regulates the formation of the DNA double-strand breaks that initiate recombination by phosphorylating the Mer2/Rec107 protein and thereby modulating interactions of Mer2 with other proteins required for break formation. We propose that this function of Cdc28 helps to coordinate the events of meiotic prophase with each other and with progression through prophase. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | protein phosphorylation; unclassified drug; nonhuman; dna replication; protein function; dna recombination; meiosis; models, biological; protein protein interaction; protein; phosphorylation; dna strand breakage; regulatory mechanism; amino acid sequence; molecular sequence data; saccharomyces cerevisiae; chromatin; recombination, genetic; mutagenesis, site-directed; binding sites; budding; yeast; saccharomyces cerevisiae proteins; saccharomycetales; cyclin dependent kinase; chromosomes, fungal; cyclin dependent kinase 1; prophase; dna, fungal; cdc28 protein kinase, s cerevisiae; mer2 protein; rec107 protein |
| Journal Title: | Cell |
| Volume: | 125 |
| Issue: | 7 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2006-06-30 |
| Start Page: | 1321 |
| End Page: | 1332 |
| Language: | English |
| DOI: | 10.1016/j.cell.2006.04.039 |
| PUBMED: | 16814718 |
| PROVIDER: | scopus |
| PMCID: | PMC1950680 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 49" - "Export Date: 4 June 2012" - "CODEN: CELLB" - "Source: Scopus" |
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