Replisome assembly and the direct restart of stalled replication forks Journal Article

  


Authors: Heller, R. C.; Marians, K. J.
Article Title: Replisome assembly and the direct restart of stalled replication forks
Abstract: Failure to reactivate either stalled or collapsed replication forks is a source of genomic instability in both prokaryotes and eukaryotes. In prokaryotes, dedicated fork repair systems that involve both recombination and replication proteins have been identified genetically and characterized biochemically. Replication conflicts are solved through several pathways, some of which require recombination and some of which operate directly at the stalled fork. Some recent biochemical observations support models of direct fork repair in which the removal of the blocking template lesion is not always required for replication restart. © 2006 Nature Publishing Group.
Keywords: dna binding protein; dna-binding proteins; review; nonhuman; dna replication; genetic analysis; protein analysis; dna recombination; animals; dna repair; protein assembly; dna; eukaryota; recombination, genetic; genomic instability; dna structure; dna replication origin; dna helicases; protein dna interaction; replicon; replisome; prokaryote; prokaryota; eukaryotic cells; dna replication fork; prokaryotic cells
Journal Title: Nature Reviews Molecular Cell Biology
Volume: 7
Issue: 12
ISSN: 1471-0072
Publisher: Nature Publishing Group  
Date Published: 2006-12-01
Start Page: 932
End Page: 943
Language: English
DOI: 10.1038/nrm2058
PUBMED: 17139333
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33845330910&partnerID=40&md5=2b3975b690bff830945bc847fbf58b1f
Notes: --- - "Cited By (since 1996): 106" - "Export Date: 4 June 2012" - "CODEN: NRMCB" - "Source: Scopus"
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MSK Authors
  1. Ryan Heller
    2 Heller
  2. Kenneth Marians
    138 Marians
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