Effect of mammography on breast cancer risk in women with mutations in BRCA1 or BRCA2 Journal Article


Authors: Goldfrank, D.; Chuai, S.; Bernstein, J. L.; Ramón Y Cajal, T.; Lee, J. B.; Alonso, M. C.; Diez, O.; Baiget, M.; Kauff, N. D.; Offit, K.; Robson, M.
Article Title: Effect of mammography on breast cancer risk in women with mutations in BRCA1 or BRCA2
Abstract: Women who carry mutations in either the BRCA1 or BRCA2 genes are at risk for early-onset breast cancer and are recommended to begin screening mammography at age 25 to 30 years. Results of in vitro and animal studies suggest that BRCA1/BRCA2 mutation carriers are hypersensitive to ionizing radiation and possibly to radiation-induced breast cancer. This study was undertaken to investigate the association of low-dose radiation exposure from mammograms with breast cancer status in BRCA mutation carriers. One hundred sixty-two female mutation carriers provided information at time of genetic testing about exposure to mammograms before enrollment. Using unconditional logistic regression, breast cancer status was not associated with number of mammograms received before diagnosis (affected women) or ascertainment [unaffected women; adjusted odds ratio (OR), 0.94; P = not significant]. A larger group of 213 women provided information about lifetime number of mammograms. There was no association between mammogram exposure and risk in the group as a whole (adjusted OR, 1.04; P = not significant), although there was a modest association in BRCA1 carriers (adjusted OR, 1.08; P = 0.03). These findings indicate that screening mammography is unlikely to be associated with a large increase in breast cancer risk in this population. Copyright © 2006 American Association for Cancer Research.
Keywords: adult; controlled study; aged; middle aged; gene mutation; major clinical study; mutation; cancer risk; genetic analysis; breast cancer; odds ratio; cancer screening; mass screening; in vitro study; brca1 protein; brca2 protein; heterozygote; radiation exposure; outcome assessment (health care); questionnaires; risk; mammography; early diagnosis; genes, brca1; genes, brca2; ionizing radiation; radiosensitivity; logistic regression analysis
Journal Title: Cancer Epidemiology Biomarkers and Prevention
Volume: 15
Issue: 11
ISSN: 1055-9965
Publisher: American Association for Cancer Research  
Date Published: 2006-11-01
Start Page: 2311
End Page: 2313
Language: English
DOI: 10.1158/1055-9965.epi-06-0176
PUBMED: 17119064
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 26" - "Export Date: 4 June 2012" - "CODEN: CEBPE" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Shaokun Chuai
    29 Chuai
  2. Kenneth Offit
    521 Offit
  3. Mark E Robson
    372 Robson
  4. Noah Kauff
    122 Kauff
  5. Jonine L Bernstein
    104 Bernstein
  6. Johanna Lee
    8 Lee