Medulloblastoma: Therapy and biologic considerations Journal Article


Authors: Gershon, T. R.; Becher, O. J.
Article Title: Medulloblastoma: Therapy and biologic considerations
Abstract: Tremendous strides have been made in both the treatment and the biologic understanding of medulloblastoma. Present optimal treatment can cure most medulloblastoma patients. A substantial minority of patients, however, will have recurrent or progressive disease. Recent studies have demonstrated that the success of treatment is not simply a matter of chance, but rather can be predicted based on specific biologic markers. These markers predict outcome independent of clinical staging and make clear that medulloblastomas are a biologically diverse group of tumors with variable clinical behavior. Molecular biologic investigation, including replication of tumorigenesis in transgenic mice, has further elucidated the complex biology of medulloblastoma. Current standard and investigational treatments, however, do not yet make use of biologic markers that predict risk of recurrence. Practical limitations have slowed the pace at which treatment paradigms can be revised to incorporate biologic insights. Mouse medulloblastoma models may provide an important bridge between biologic investigation and the development of new therapeutic approaches. Copyright © 2006 by Current Science Inc.
Keywords: protein kinase b; somatomedin; cancer survival; protein expression; cancer recurrence; cisplatin; cancer combination chemotherapy; nonhuman; cancer radiotherapy; cancer staging; neurotoxicity; genetic analysis; biological marker; animals; sonic hedgehog protein; risk factors; cyclophosphamide; vincristine; clinical protocol; drug evaluation, preclinical; protein p53; prediction; lomustine; risk assessment; carcinogenesis; transgenic mouse; cancer genetics; patient care; myc protein; medulloblastoma; outcomes research; cyclopamine; cancer classification; molecular biology; disease models, animal; hematologic disease; ototoxicity; disease activity; polyneuropathy
Journal Title: Current Neurology and Neuroscience Reports
Volume: 6
Issue: 3
ISSN: 1528-4042
Publisher: Springer  
Date Published: 2006-05-01
Start Page: 200
End Page: 206
Language: English
DOI: 10.1007/s11910-006-0006-y
PUBMED: 16635428
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 4 June 2012" - "CODEN: CNNRB" - "Source: Scopus"
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MSK Authors
  1. Timothy Robin Gershon
    11 Gershon
  2. Oren Josh Becher
    25 Becher