Paraneoplastic syndromes affecting the nervous system Journal Article
| Authors: | Darnell, R. B.; Posner, J. B. |
| Article Title: | Paraneoplastic syndromes affecting the nervous system |
| Abstract: | The paraneoplastic neurologic disorders (PND) are a diverse group of diseases characterized by the presence of neurologic dysfunction in the setting of a remote cancer. PND can affect almost any part of the nervous system, and are most commonly associated with lung cancer (small cell) and gynecologic tumors. Laboratory studies have demonstrated that an autoimmune response links the neurologic disorder and the cancer, and established a model whereby the cancer is believed to initiate the syndrome by expressing a protein antigen normally expressed in the nervous system, leading to anti-tumor immune response followed by autoimmune neurologic symptoms. We review the currently known PND and their pathogenesis. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; protein expression; prednisone; clinical feature; fluorouracil; cytarabine; methotrexate; rituximab; nuclear magnetic resonance imaging; positron emission tomography; antineoplastic agent; diagnostic procedure; unindexed drug; sensory neuropathy; lung neoplasms; differential diagnosis; incidence; cyclophosphamide; dexamethasone; melphalan; plasmapheresis; waldenstroem macroglobulinemia; genital neoplasms, female; prednisolone; immune response; immunoglobulin g; brain; spinal cord; hypothalamus; retinopathy; autoimmunity; dermatomyositis; azathioprine; anticonvulsive agent; corticosteroid; cerebrospinal fluid analysis; eaton lambert syndrome; immunosuppressive treatment; myasthenia gravis; opsoclonus; paraneoplastic syndrome; stiff man syndrome; autoimmune diseases; tacrolimus; clonazepam; brain stem; disease exacerbation; autoantibodies; cyclosporin; phenytoin; autonomic neuropathy; chlorambucil; cranial neuropathy; drug induced disease; sensorimotor neuropathy; peripheral nervous system diseases; immunosuppressive agent; myeloma; spinal cord disease; carbamazepine; benzodiazepine; paraneoplastic neuropathy; carcinoma, small cell; muscle relaxant agent; retina cone; myopathy; spinal ganglion; visual acuity; corticotropin; nervous system diseases; plasma cell dyscrasia; vasculitis; guillain barre syndrome; neuromuscular junction diseases; retina disease; myelitis; encephalomyelitis; 3,4 diaminopyridine; motor neuron disease; myokymia; central nervous system diseases; diazepam; paraneoplastic syndromes; mycophenolic acid; optic nerve disease; cryoglobulinemia; enolase; baclofen |
| Journal Title: | Seminars in Oncology |
| Volume: | 33 |
| Issue: | 3 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-06-01 |
| Start Page: | 270 |
| End Page: | 298 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2006.03.008 |
| PUBMED: | 16769417 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 49" - "Export Date: 4 June 2012" - "CODEN: SOLGA" - "Source: Scopus" |
