Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition Journal Article
| Authors: | Capote, R.; Alonso-Lebrero, J. L.; García, F.; Brieva, A.; Pivel, J. P.; Gonzalez, S. |
| Article Title: | Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition |
| Abstract: | In this report, we demonstrate a possible molecular mechanism by which a hydrophilic extract of the leaves of the fern Polypodium leucotomos (Fernblock®, PL) blocks ultraviolet (UV)-induced skin photodamage. The extract inhibits UVA and UVB light induced photoisomerization of trans-urocanic acid (t-UCA), a common photoreceptor located in the stratum corneum, and also blocks its photodecomposition in the presence of oxidizing reagents such as H 2O 2, and titanium dioxide (TiO 2). PL protects in vitro human fibroblasts from UV-induced death as well. These results suggest the potential of employing the PL extract as a component of sunscreen moistures in order to prevent photodecomposition of t-UCA, to inhibit UV-induced deleterious effects of TiO 2 and to protect skin cells and endogenous molecules directly involved in skin immunosurveillance. © 2005 Elsevier B.V. All rights reserved. |
| Keywords: | controlled study; human cell; ultraviolet radiation; cell death; cells, cultured; sunscreen; drug mechanism; reactive oxygen species; hydrogen peroxide; plant leaf; immunosurveillance; ultraviolet a radiation; ultraviolet b radiation; ultraviolet rays; cell protection; titanium; drug formulation; polypodium leucotomos extract; skin fibroblast; polypodium; stratum corneum; photoreceptor; photochemistry; isomerization; skin injury; filicophyta; polypodium (plant); polypodium leucotomos; titanium dioxide; light damage; photodegradation; h; 2o; photoisomerization; urocanic acid; fernblock; oxidizing agent |
| Journal Title: | Journal of Photochemistry and Photobiology B: Biology |
| Volume: | 82 |
| Issue: | 3 |
| ISSN: | 1011-1344 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2006-03-01 |
| Start Page: | 173 |
| End Page: | 179 |
| Language: | English |
| DOI: | 10.1016/j.jphotobiol.2005.11.005 |
| PUBMED: | 16388959 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 June 2012" - "CODEN: JPPBE" - "Source: Scopus" |
