Increased risk for abnormalities on perioperative colon screening in patients with microsatellite instability-positive endometrial carcinoma Journal Article
| Authors: | Buttin, B. M.; Powell, M. A.; Goodfellow, P. J.; Lewin, S. N.; Gibb, R. K.; Mutch, D. G. |
| Article Title: | Increased risk for abnormalities on perioperative colon screening in patients with microsatellite instability-positive endometrial carcinoma |
| Abstract: | Microsatellite instability (MSI) is a feature of certain hereditary and sporadic endometrial and colon cancers. We set out to determine whether molecular stratification of endometrial cancers based on tumor MSI status could help identify patients at increased risk for abnormalities found on perioperative colon screening. From a prospectively accrued series of 413 patients, medical records were reviewed from 94 patients with MSI positive (MSI+) and 94 patients with MSI negative (MSI-) endometrial cancers, matched by year of diagnosis. We reviewed clinicopathologic data and results of perioperative colon screening. Differences were analyzed using Fisher exact test and logistic regression analysis. There were no significant clinicopathologic differences between the two cohorts. Sixty-five percent of patients in each group underwent perioperative colon screening. However, patients with MSI+ cancers had a twofold increase in the frequency of colonic abnormalities (30% versus 14.8%, P = 0.044) over those with MSI- cancers. Furthermore, the only primary colon cancers (N = 2) were found in women with MSI+ endometrial cancers that were unmethylated at the MLH1 promoter. Our data suggest that patients with MSI+ endometrial cancers are at increased risk for abnormalities on perioperative colon screening. Those with MSI+ MLH1 unmethylated cancers appear to be at highest risk. © 2006, IGCS and ESGO. |
| Keywords: | adolescent; human tissue; middle aged; major clinical study; promoter region; histopathology; review; cancer risk; endometrial cancer; endometrium carcinoma; endometrial neoplasms; preoperative evaluation; prospective study; gene; colonic neoplasms; cohort analysis; risk factors; cancer screening; mass screening; dna methylation; risk assessment; nuclear proteins; cancer genetics; colonoscopy; colon cancer; microsatellite instability; carrier proteins; medical record; logistic regression analysis; fisher exact test; mlh1 gene; clinical examination; promoter regions (genetics); colon screening |
| Journal Title: | International Journal of Gynecological Cancer |
| Volume: | 16 |
| Issue: | 6 |
| ISSN: | 1048-891X |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2006-11-01 |
| Start Page: | 1980 |
| End Page: | 1986 |
| Language: | English |
| DOI: | 10.1111/j.1525-1438.2006.00735.x |
| PUBMED: | 17177835 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 4 June 2012" - "CODEN: IJGCE" - "Source: Scopus" |
