Clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma Journal Article
| Authors: | Black, D.; Soslow, R. A.; Levine, D. A.; Tornos, C.; Chen, S. C.; Hummer, A. J.; Bogomolniy, F.; Olvera, N.; Barakat, R. R.; Boyd, J. |
| Article Title: | Clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma |
| Abstract: | Purpose: Defective DNA mismatch repair is commonly present in sporadic manifestations of gastrointestinal, endometrial, and other cancers. The pathognomonic molecular manifestation of this repair defect is microsatellite instability (MSI). Here, we test the hypothesis that MSI predicts the clinicopathologic features of endometrial carcinoma. Patients and Methods: A retrospective cohort of 473 patients treated for endometrial carcinoma at this institution was identified. All cases were reviewed by a gynecologic pathologist, and clinical information was abstracted from medical records. Using consensus criteria, DNA samples from nontumor and tumor tissue pairs were genotyped for MSI. Associations between MSI status and pathologic and clinical variables were assessed. Results: Ninety-three (20%) of 473 tumors were MSI+. In the MSI+ tumor group compared with the MSI-tumor group, the proportion of advanced compared with early-stage tumors was higher (92% v 81 %; P = .01), as was the proportion of tumors of endometrioid compared with nonendometrioid histologic subtype (94% v23%; P = .001), and the proportion of tumors with myometrial invasion compared with those with none (92% v 78%; P = .01). By multivariate analyses, disease-free survival (hazard ratio, 0.3; 95% CI, 0.2 to 0.7) and disease-specific survival (hazard ratio, 0.3; 95% CI, 0.1 to 0.8) were significantly improved in patients with MSI+ tumors. Conclusion: In endometrial carcinoma, the presence of MSI was independently associated with a more favorable clinical outcome. © 2006 by American Society of Clinical Oncology. |
| Keywords: | adult; cancer survival; controlled study; human tissue; aged; disease-free survival; retrospective studies; major clinical study; genetics; mutation; clinical feature; mortality; disease free survival; endometrium carcinoma; endometrial neoplasms; consensus; clinical assessment; cohort analysis; genotype; pathology; retrospective study; cancer invasion; patient information; mismatch repair; microsatellite instability; medical record; molecular biology; endometrium tumor; dna determination; germ-line mutation; disorders of dna synthesis and repair; dna repair-deficiency disorders |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 24 |
| Issue: | 11 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2006-04-10 |
| Start Page: | 1745 |
| End Page: | 1753 |
| Language: | English |
| DOI: | 10.1200/jco.2005.04.1574 |
| PUBMED: | 16549821 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 45" - "Export Date: 4 June 2012" - "CODEN: JCOND" - "Source: Scopus" |
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