Alterations of the retinoblastoma and p16 pathway correlate with promoter methylation in malignant fibrous histiocytomas Journal Article
| Authors: | Brinck, U.; Schlott, T.; Störber, S.; Stachura, J.; Bortkiewicz, P.; Nagel, W. D.; Hasse, F. M.; Cordon-Cardo, C.; Fischer, G.; Korabiowska, M. |
| Article Title: | Alterations of the retinoblastoma and p16 pathway correlate with promoter methylation in malignant fibrous histiocytomas |
| Abstract: | Recent reports indicate that the alterations in the p16 and pRb pathways can influence tumour progression and poor prognosis in several tumours. The objective of this study was to analyse p16 and pRb expression in161 patients with malignant fibrous histiocytomas (MFH). By immunohistochemistry, p16 and pRb were demonstrated in 25% and 56% of MFH, respectively. Cox regression analysis demonstrated an independent prognostic influence of both genes. Generally, the loss of p16 and pRb expression correlated with poorer prognosis. Promoter methylation of p16 was found in 16/42 of p16 negative MFH and of pRb in 2/42 of pRb-negative MFH. It can be concluded that p16 and pRb alterations play an important role in the progression of soft tissue sarcomas. |
| Keywords: | immunohistochemistry; signal transduction; adult; cancer survival; controlled study; human tissue; protein expression; human cell; major clinical study; methylation; promoter region; cell cycle; protein p16; retinoblastoma; dna methylation; immunoenzyme techniques; proportional hazards model; soft tissue sarcoma; cyclin-dependent kinase inhibitor p16; tumor growth; malignant fibrous histiocytoma; retinoblastoma protein; p16; promoter methylation; histiocytoma, malignant fibrous; promoter regions (genetics); fibrous histiocytoma; prb pathway |
| Journal Title: | Anticancer Research |
| Volume: | 26 |
| Issue: | 5A |
| ISSN: | 0250-7005 |
| Publisher: | International Institute of Anticancer Research |
| Date Published: | 2006-09-01 |
| Start Page: | 3461 |
| End Page: | 3465 |
| Language: | English |
| PUBMED: | 17094467 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 4 June 2012" - "CODEN: ANTRD" - "Source: Scopus" |
