Giving blood: A new role for CD40 in tumorigenesis Journal Article
| Authors: | Bergmann, S.; Pandolfi, P. P. |
| Article Title: | Giving blood: A new role for CD40 in tumorigenesis |
| Abstract: | CD40 was initially identified as a receptor expressed by B cells that is crucial for inducing an effective adaptive immune response. CD40 was subsequently shown to be expressed by endothelial cells and to promote angiogenesis. New data now show that in tumor-prone transgenic mice, CD40-mediated neovascularization is essential for early stage tumorigenicity. This suggests, at least in this mouse model, that CD40 has an important role in the angiogenic process that is coupled to carcinogenesis, a finding that could lead to novel therapeutic opportunities. JEM © The Rockefeller University Press. |
| Keywords: | signal transduction; vasculotropin; protein expression; review; angiogenesis inhibitor; nonhuman; drug targeting; antigen expression; animals; cd40 ligand; fas ligand; angiogenesis; neovascularization, pathologic; b lymphocyte; carcinogenesis; transgenic mouse; endothelium cell; fibroblast growth factor 2; immune response; drug mechanism; cd4+ t lymphocyte; clopidogrel; tumor growth; thrombospondin 1; tumor vascularization; neovascularization (pathology); mammary neoplasms, experimental; antigens, cd40; cd40 antigen; cd36 antigen; fibroblast growth factor 1 |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 203 |
| Issue: | 11 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2006-10-30 |
| Start Page: | 2409 |
| End Page: | 2412 |
| Language: | English |
| DOI: | 10.1084/jem.20061754 |
| PUBMED: | 17043147 |
| PROVIDER: | scopus |
| PMCID: | PMC2118122 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 4 June 2012" - "CODEN: JEMEA" - "Source: Scopus" |
