Trends in the use of postoperative radiotherapy for resected non-small-cell lung cancer Journal Article

  


Authors: Bekelman, J. E.; Rosenzweig, K. E.; Bach, P. B.; Schrag, D.
Article Title: Trends in the use of postoperative radiotherapy for resected non-small-cell lung cancer
Abstract: Purpose: A 1998 meta-analysis of postoperative radiotherapy (PORT) for non-small-cell lung cancer (NSCLC) found that PORT did not improve outcomes. Yet practice guidelines differ in their recommendations with regard to PORT use. We examine temporal trends in PORT use before and after the 1998 meta-analysis. Methods and Materials: Using data from the Surveillance, Epidemiology, and End Results (SEER) Program, we identified 22,953 patients with Stage I, II, or IIIA NSCLC who had resection between 1992 and 2002 in the United States and characterized each patient according to nodal status (N0, N1, or N2 disease). We measured use of PORT by calendar year. We examined the association between clinical and demographic characteristics and receipt of PORT using logistic regression. Results: For N0, N1, and N2 NSCLC, PORT use has declined. The proportion of patients with N0 disease receiving PORT declined from 8% in 1992 to 4% in 2002. For patients with N1 disease, PORT use declined from 51% in 1992 to 19% in 2002; and for patients with N2 disease, PORT use declined from 65% in 1992 to 37% in 2002. Conclusion: In the context of uncertainty about what constitutes optimal adjuvant treatment for resected NSCLC, PORT use has substantially declined. © 2006 Elsevier Inc. All rights reserved.
Keywords: adult; aged; aged, 80 and over; middle aged; treatment failure; clinical trial; postoperative period; cancer adjuvant therapy; cancer radiotherapy; radiotherapy, adjuvant; cancer staging; demography; lung non small cell cancer; lung resection; carcinoma, non-small-cell lung; lung neoplasms; radiotherapy; practice guideline; tumors; outcomes research; health services research; seer program; patient treatment; disease control; regression analysis; logistic regression analysis; postoperative radiotherapy; meta analysis; non-small-cell lung cancer; uncertainty; seer; practice patterns; data acquisition; uncertain systems
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Volume: 66
Issue: 2
ISSN: 0360-3016
Publisher: Elsevier Inc.  
Date Published: 2006-10-01
Start Page: 492
End Page: 499
Language: English
DOI: 10.1016/j.ijrobp.2006.04.032
PUBMED: 16814952
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33748286679&partnerID=40&md5=fac5fae830103edc4155e478a44d1fa0
Notes: --- - "Cited By (since 1996): 15" - "Export Date: 4 June 2012" - "CODEN: IOBPD" - "Source: Scopus"
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MSK Authors
  1. Justin Bekelman
    18 Bekelman
  2. Deborah Schrag
    229 Schrag
  3. Kenneth E Rosenzweig
    165 Rosenzweig
  4. Peter Bach
    255 Bach
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