Nonpalpable mammographically occult invasive breast cancers detected by MRI Journal Article
| Authors: | Bartella, L.; Liberman, L.; Morris, E. A.; Dershaw, D. D. |
| Article Title: | Nonpalpable mammographically occult invasive breast cancers detected by MRI |
| Abstract: | OBJECTIVE. The purpose of this study was to determine the MRI findings and histology of clinically and mammographically occult invasive breast cancers detected by MRI. MATERIALS AND METHODS. A retrospective review was undertaken of 1,336 breast MRI examinations performed during a 2-year period. Among these, 68 nonpalpable mammographically occult invasive cancers were identified in 57 women with a median age of 50 years (range, 30-72 years). MRI findings were classified according to the breast MRI lexicon. Medical records were reviewed to determine the histology. RESULTS. Indications for performing MRI were extent of disease assessment in 72% (41/57), high-risk screening in 25% (14/57), and problem solving in 3% (2/57). MRI lesion types in these 68 invasive cancers were nonmass in 57% (39/68) and mass in 43% (29/68). Kinetics were plateau in 59% (40/68), washout in 38% (26/68), and persistent in 3% (2/68). Histology was invasive ductal cancer in 65% (44/68), mixed invasive ductal and lobular cancer in 19% (13/68), and invasive lobular cancer in 16% (11/68). The cancer stage was I in 61% (34/56), II in 32% (18/56), and more advanced in 7% (4/56). Sixty-three percent (43/68) of lesions were minimal cancers, defined as invasive cancers measuring under 1 cm. CONCLUSION. In this study of mammographically and clinically occult cancers detected by MRI, 57% (39/68) of invasive breast cancers were evident as nonmass enhancement, and 63% were minimal breast cancers. © American Roentgen Ray Society. |
| Keywords: | adult; aged; middle aged; retrospective studies; major clinical study; histopathology; review; cancer staging; nuclear magnetic resonance imaging; methodology; magnetic resonance imaging; cancer diagnosis; breast cancer; pathology; breast neoplasms; retrospective study; high risk patient; cancer invasion; mammography; diagnostic value; breast tumor; radiography; problem solving; neoplasm invasiveness; screening test; intraductal carcinoma; mri; occult cancer |
| Journal Title: | American Journal of Roentgenology |
| Volume: | 186 |
| Issue: | 3 |
| ISSN: | 0361-803X |
| Publisher: | American Roentgen Ray Society |
| Date Published: | 2006-03-01 |
| Start Page: | 865 |
| End Page: | 870 |
| Language: | English |
| DOI: | 10.2214/ajr.04.1777 |
| PUBMED: | 16498122 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 28" - "Export Date: 4 June 2012" - "CODEN: AJROA" - "Source: Scopus" |
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