p53, epidermal growth factor, and platelet-derived growth factor in uterine leiomyosarcoma and leiomyomas Journal Article

Authors: Anderson, S. E.; Nonaka, D.; Chuai, S.; Olshen, A. B.; Chi, D.; Sabbatini, P.; Soslow, R. A.
Article Title: p53, epidermal growth factor, and platelet-derived growth factor in uterine leiomyosarcoma and leiomyomas
Abstract: Uterine leiomyosarcoma (ULMS) is an aggressive gynecological disease. Although ULMS are often found in association with benign leiomyoma (LMA), little is known regarding the relationship between these benign and malignant smooth muscle neoplasms. The objective of this study was to evaluate the expression of epidermal growth factor (EGFR), platelet-derived growth factor (PDGFR), and p53 in ULMS specimens, their prognostic relevance, and the expression of these molecular markers when compared to benign LMA specimens. Between 1991 and 2001, 25 patients were identified with high-grade primary ULMS and for whom tissue was available. Tissue microarray was created with three representative cores from each of the ULMS cases as well as from 19 patients with benign uterine leiomyomata. Immunohistochemical (IHC) staining was performed for EGFR, PDGFR, and p53. Negative and positive IHC staining was scored for each marker. Outcome analysis was performed only for ULMS. Survival was determined from the time of initial diagnosis to last follow-up. Twelve (48%) ULMS expressed p53 compared to none of the LMA (P < 0.001), and 15 (60%) ULMS cases showed PDGFR expression compared to 32% of LMA samples (P= 0.08). EGFR expression did not differ between ULMS and LMA groups. ULMS patients with p53 expression had a poorer survival compared to ULMS patients with negative expression (P= 0.07). ULMS tumor stage had the strongest association with overall survival (P= 0.05). Our study supports previous investigations indicating that p53 expression may serve as a prognostic marker for ULMS patients. The difference in PDGFR expression between ULMS and LMA demonstrated a trend toward significance. EGFR was not commonly expressed in ULMS. These uniquely expressed markers may assist in stratifying patients by survival and identify novel therapeutic markers. Clearly, further investigation is needed. © 2006, IGCS.
Keywords: immunohistochemistry; epidermal growth factor; platelet derived growth factor; adult; cancer survival; clinical article; controlled study; human tissue; protein expression; aged; disease-free survival; middle aged; survival rate; cancer patient; cell death; protein p53; molecular marker; immunoenzyme techniques; platelet-derived growth factor; tumor suppressor protein p53; malignant neoplastic disease; tissue microarray; leiomyosarcoma; hormonal regulation; uterine neoplasms; uterus myoma; uterus tumor; leiomyoma; gynecologic disease
Journal Title: International Journal of Gynecological Cancer
Volume: 16
Issue: 2
ISSN: 1048-891X
Publisher: Lippincott Williams & Wilkins  
Date Published: 2006-03-01
Start Page: 849
End Page: 853
Language: English
DOI: 10.1111/j.1525-1438.2006.00542.x
PUBMED: 16681772
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 15" - "Export Date: 4 June 2012" - "CODEN: IJGCE" - "Source: Scopus"
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MSK Authors
  1. Daisuke Nonaka
    6 Nonaka
  2. Shaokun Chuai
    29 Chuai
  3. Dennis S Chi
    496 Chi
  4. Paul J Sabbatini
    201 Sabbatini
  5. Adam B Olshen
    107 Olshen
  6. Robert Soslow
    643 Soslow